{"id":133175,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":""},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-de-bioequivalencia-tras-dosis-unica-oral-en-sujetos-sanos-de-un-farmaco-psicoactivo-morfina-entre-formulaciones-de-liberacion-modificada-evaluacion-farmacocinetica-y-farmacodinamica-dife","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-bioequivalencia-tras-dosis-unica-oral-en-sujetos-sanos-de-un-farmaco-psicoactivo-morfina-entre-formulaciones-de-liberacion-modificada-evaluacion-farmacocinetica-y-farmacodinamica-dife\/","title":{"rendered":"Estudio de bioequiValencia (tras dosis unica oral en sujetos sanos) de un farmaco psicoactivo (morfina) entre formulaciones de liberacion modificada: evaluacion farmacocinetica y farmacodinamica. diferencias segun el sexo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Graciela Salazar Vargas <\/strong><\/h2>\n<p>Objetivos: determinar: 1.- La biodisponibilidad (bd) y bioequiValencia (be) entre dos formulaciones de comprimidos orales de liberacion modificad. 2.- El tipo de perfil farmacocinetico \u00abin vivo\u00bb que muestra la fi de morfina de liberacion modificada. 3.- Los parametros apicales propuesto para formulaciones orales de liberacion modificada. 4.- El efecto neurofisiologico de la morfina a concentraciones bajas (eeg). 5.- Los efectos subjetivos a concentraciones bajas. 6.- La tolerabilidad de los tratamientos, a concentraciones bajas. 7.- Si existen diferencias en funcion del sexo en la pk y pd de la morfina.  sujetos: 16 sujetos jovenes de ambos sexos (8 h: 8 m).  tratamientos: sulfato de morfina 30 mg (mst continus (fr), clorhidrato de morfina 30mg morfina 30 mg (fi), placebo (pla), dise\u00f1o: orden aleatorio de los tratamientos, cruzado, doble ciego, controlado com pla.  metodo analitico: ria (cout a count dpc). Variables farmacocineticas: a) concentraciones plasmaticas de morfina total (mt) y de morfina libre (ml). B) parametros farmacocineticos de be: c max, cmax\/abc0, abc 0 24, abc 0, y sus log, tmax c) parametros farmacocineticos adicionales ka, tmr, vtmr, vd\/f, kel, cl\/f, t 1\/2. D) apicales cap, tap1, tap2, tap1-2 variables farmacodinamicas a) cartografia topografica de la feeg-c:  v-eeg, b) de la feeg-c: v-eeg. B) escalas de valoracion subjetiva: v-de, v-acp, v-ec, v-nc, v-sd, pd, p-ac, p-e, p-an, p-s. Tolerabilidad: a) ees, opi. B) constantes vitales: variables hemodinamicas y frecuencia respiratoria. C) analisis clinico-biologicos. Tiempos de lectura extracciones sanguineas: basal, + 30 minutos, + 1, +1.5, +2, +2.5, +3 +3.5, +4, +4.5, +5, +6, +7, +9, +12, +16 y +24 h post-medicacion. F-eeg-c: basal, +1.5, +3, +6, +9. Pruebas de valoracion autosubjetiva y constantes vitales: basal, +1.5, +3, +6, +9, +12 y +24.  analisis clinico-biologicos: basal y a +24 h. Opi: +24 h.  conclusiones: 1.- Tanto bajo la condicion de ml como m<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de bioequiValencia (tras dosis unica oral en sujetos sanos) de un farmaco psicoactivo (morfina) entre formulaciones de liberacion modificada: evaluacion farmacocinetica y farmacodinamica. diferencias segun el sexo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de bioequiValencia (tras dosis unica oral en sujetos sanos) de un farmaco psicoactivo (morfina) entre formulaciones de liberacion modificada: evaluacion farmacocinetica y farmacodinamica. diferencias segun el sexo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Graciela Salazar Vargas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel J Barbanoj Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francesc Jan\u00e9 Carrenca <\/li>\n<li>Mar\u00eda  Antonia Mangues Bafaully (vocal)<\/li>\n<li>M. Eulalia Planas  Domingo (vocal)<\/li>\n<li>Albert Badia Sancho (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Graciela Salazar Vargas Objetivos: determinar: 1.- La biodisponibilidad (bd) y bioequiValencia (be) entre dos formulaciones de comprimidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,9,36572,2445,957],"tags":[46,51,247159,13850,14229,85157],"class_list":["post-133175","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-medicas","category-estandarizacion-de-farmacos","category-evaluacion-de-farmacos","category-farmacologia","tag-albert-badia-sancho","tag-francesc-jane-carrenca","tag-graciela-salazar-vargas","tag-m-eulalia-planas-domingo","tag-manuel-j-barbanoj-rodriguez","tag-maria-antonia-mangues-bafaully"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=133175"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133175\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=133175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=133175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=133175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}