{"id":133214,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-del-reconocimiento-antigenico-de-las-celulas-t-el-receptor-antigenico-y-la-molecula-accesoria-cd50\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"caracterizacion-molecular-del-reconocimiento-antigenico-de-las-celulas-t-el-receptor-antigenico-y-la-molecula-accesoria-cd50","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-molecular-del-reconocimiento-antigenico-de-las-celulas-t-el-receptor-antigenico-y-la-molecula-accesoria-cd50\/","title":{"rendered":"Caracterizacion molecular del reconocimiento antigenico de las celulas t: el receptor antigenico y la molecula accesoria cd50."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jordi Yague Ribes <\/strong><\/h2>\n<p>La caracterizacion molecular del receptor antigenico de los linfocitos t humanos (tcr) es abordada mediante el aislamiento de los genes correspondientes a las cadenas alfa y beta del tcr. Se analiza la secuencia nucleotidica de estos genes, su expresion, el reordenamiento genetico durante la diferenciacion timica y su participacion en el reconocimiento antigenico de los linfocitos t. Este ultimo apartado, gracias a modelos de complementacion genica entre variantes negativas de hibridomas t murinos.  se demuestra de forma concluyente, que son las cadenas alfa y beta del receptor antigenico de los linfocitos t las responsables del reconocimiento del complejo formado por el antigeno i las moleculas del mhc. En un segundo apartado, se analiza el papel de la molecula accesoria cd50 o icam-3 en el reconocimiento antigenico de los linfocitos t. Tras su caracterizacion genetica i molecular, se pone de manifiesto la capacidad de esta molecula de adhesion para transducir se\u00f1ales activadoras al interior de la celula. Se analiza la capacidad del cd50 para inducir un estado de alta adhesividad mediado por las integrinas beta 1 y beta 2. Que mantiene a los linfocitos unidos a celulas endoteliales. Finalmente se plantea una hipotesis integradora del reconocimiento antigenico de los linfocitos t.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion molecular del reconocimiento antigenico de las celulas t: el receptor antigenico y la molecula accesoria cd50.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion molecular del reconocimiento antigenico de las celulas t: el receptor antigenico y la molecula accesoria cd50. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jordi Yague Ribes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Vives Puigros<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Oriol Bachs Valldeneu <\/li>\n<li>Jaume Martorell Pons (vocal)<\/li>\n<li>Dolores Jaraquemada P\u00e9rez De Guzm\u00e1n (vocal)<\/li>\n<li>Oscar De La Calle Martin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jordi Yague Ribes La caracterizacion molecular del receptor antigenico de los linfocitos t humanos (tcr) es abordada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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