{"id":13326,"date":"2018-03-09T08:59:34","date_gmt":"2018-03-09T08:59:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-una-vacuna-subcelular-frente-a-la-brucelosis-con-microparta%c2%adculas-biodegradables-como-adyuvante\/"},"modified":"2018-03-09T08:59:34","modified_gmt":"2018-03-09T08:59:34","slug":"desarrollo-de-una-vacuna-subcelular-frente-a-la-brucelosis-con-microparta%c2%adculas-biodegradables-como-adyuvante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/desarrollo-de-una-vacuna-subcelular-frente-a-la-brucelosis-con-microparta%c2%adculas-biodegradables-como-adyuvante\/","title":{"rendered":"Desarrollo de una vacuna subcelular frente a la brucelosis con micropart\u00edculas biodegradables como adyuvante"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Murillo Mart\u00edn M. Isabel <\/strong><\/h2>\n<p>La brucelosis es una zoonosis que afecta a distintas especies animales, principalmente al ganado ovino, caprino y bovino. En estos animales la enfermedad pude causar abortos, nacimiento de animales inviables e infertilidad, siendo un gran problema socio-econ\u00f3mico. Por otra parte, anualmente se reportan oficialmente 500.000 casos de brucelosis humana en el planeta, aunque las cifras reales podr\u00edan cuadriplicar \u00e9stas. Las vacunas actualmente en uso consisten en bacterias vivas atenuadas. Sin embargo, a pesar de su relativa buena eficacia, presentan ciertos inconvenientes ya que interfieren en el diagn\u00f3stico y presentan cierta virulencia residual, por lo que pueden producir abortos y ser incluso pat\u00f3genas para el hombre.  el objetivo de este trabajo de investigaci\u00f3n ha sido el desarrollo de una nueva vacuna avirulenta frente a la brucelosis, basada en la microencapsulaci\u00f3n de un extracto subcelular de brucella ovis como componente inmunog\u00e9nico (hs).  para ello, se utilizaron pol\u00edmeros biodegradables (poli-*-caprolactona o poli-l\u00e1ctico-glic\u00f3lico) y una serie de excipientes (pluronic f-68, tween 20 \u00f3 polivinilpirrolidona k-25) para la fabricaci\u00f3n de micropart\u00edculas biodegradables por el m\u00e9todo de evaporaci\u00f3n del disolvente. Todas las formulaciones preparadas presentaron un di\u00e1metro inferior a 5 um. Las eficacias de encapsulaci\u00f3n variaron seg\u00fan las formulaciones, oscilando alrededor del 30%. En cuanto a la liberaci\u00f3n in vitro, las formulaciones, oscilando alrededor del 30%. en cuanto a la liberaci\u00f3n in vitro, las formulaciones \u00abpoli-*-caprolactona-pluronic\u00bb \u00abpoli-l\u00e1ctico-glic\u00f3lico-tween-20\u00bb liberaron el extracto antig\u00e9nico de una manera pulsatil en el tiempo. La formulaciones de poli-*-caprolactona fueron las m\u00e1s endocitadas por c\u00e9lulas monocito-macrof\u00e1gico, induciendo adem\u00e1s su activaci\u00f3n. En cuando a la respuesta inmune celular la formulaci\u00f3n de poli-*-caprolactona elegida indujo por v\u00eda subcut\u00e1nea, altos nivel<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de una vacuna subcelular frente a la brucelosis con micropart\u00edculas biodegradables como adyuvante<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de una vacuna subcelular frente a la brucelosis con micropart\u00edculas biodegradables como adyuvante <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Murillo Mart\u00edn M. Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Gamazo De La Rasilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Luis D\u00edaz Garc\u00eda <\/li>\n<li> Torres trillo Juan  Mar\u00eda (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Blasco Martinez (vocal)<\/li>\n<li>Juan  Manuel Irache garreta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Murillo Mart\u00edn M. Isabel La brucelosis es una zoonosis que afecta a distintas especies animales, principalmente al [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1418,35,4667,1737,278,17749,2714],"tags":[17945,43302,43303,43300,10691,43301],"class_list":["post-13326","post","type-post","status-publish","format-standard","hentry","category-bacteriologia","category-ciencias-de-la-vida","category-inmunizacion","category-inmunologia","category-microbiologia","category-navarra","category-vacunas","tag-carlos-gamazo-de-la-rasilla","tag-jose-maria-blasco-Martinez","tag-juan-manuel-irache-garreta","tag-murillo-martin-m-isabel","tag-ramon-luis-diaz-garcia","tag-torres-trillo-juan-maria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13326"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13326\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}