{"id":133308,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-apoptosis-linfocitaria-por-antigeno-de-citomegalovirus-y-su-modulacion-por-ciclosporina-a-okt3-y-farmacos-antivirales\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"caracterizacion-de-la-apoptosis-linfocitaria-por-antigeno-de-citomegalovirus-y-su-modulacion-por-ciclosporina-a-okt3-y-farmacos-antivirales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-de-la-apoptosis-linfocitaria-por-antigeno-de-citomegalovirus-y-su-modulacion-por-ciclosporina-a-okt3-y-farmacos-antivirales\/","title":{"rendered":"Caracterizacion de la apoptosis linfocitaria por antigeno de citomegalovirus y su modulacion por ciclosporina a, okt3 y farmacos antivirales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco J. Brice\u00f1o Delgado <\/strong><\/h2>\n<p>El citomegalovirus (cmv) induce en el receptor de un trasplante de organos un estado de inmunosupresion, junto con una leucocitopenia. Ambos fenomenos podrian explicarse por la capacidad que tienen algunos virus de inducir apoptosis en los linfocitos. La terapia inmunosupresora y la terapia antiviral, ambas moduladoras de la patogenia viral, pueden regular dicha apoptosis.  para demostrarlo, se realizaron cultivos linfocitarios procedentes de sujetos sanos seropositivos para cmv, estimulados con antigeno de cmv, y en presencia de ciclosporina a, anticuerpos anti-cd3 (okt3), aciclovir, ganciclovir y foscarnet. Se midio, mediante citometria de flujo, el porcentaje de linfocitos en cada fase del ciclo celular, la apoptosis linfocitaria y la expresion de antigeno cd95 (inductor de apoptosis) y proteina bcl-2 (inhibidor de apoptosis). El antigeno de citomegalovirus ocasiono una alteracion del ciclo celular caracterizada por una transicion rapida go\/s y un bloqueo de la fase de sintesis, dando lugar a una catastrofe mitotica.  desarrollo una apoptosis linfocitaria muy intensa a expensas de un incremento de antigeno cd95 y una disminucion de bcl-2. La ciclosporina a y el okt3 se comportaron como inductores debiles de la apoptosis en condiciones basales, pero inhibieron intensamente la apoptosis secundaria al antigeno viral. Ambos farmacos reestablecieron las alteraciones en el ciclo linfoproliferativo y su accion antagonista de la apoptosis fue independiente de cambios en la expresion de cd95 y\/o bcl-2. Aciclovir, ganciclovir y foscarnet no alteraron la apoptosis en reposo, pero inhibieron potentemente la apoptosis por antigeno de cmv. Los tres farmacos normalizaron la secuencia de las fases del ciclo celular. Esta inhibicion apoptosica se correspondio en el caso de ganciclovir y foscarnet con un aumento de proteina bcl-2.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion de la apoptosis linfocitaria por antigeno de citomegalovirus y su modulacion por ciclosporina a, okt3 y farmacos antivirales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion de la apoptosis linfocitaria por antigeno de citomegalovirus y su modulacion por ciclosporina a, okt3 y farmacos antivirales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco J. Brice\u00f1o Delgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Pera Madrazo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro S\u00e1nchez Guijo <\/li>\n<li>Evaristo Varo P\u00e9rez (vocal)<\/li>\n<li>Javier L\u00f3pez Pujol (vocal)<\/li>\n<li>Carlos Lumbreras Bermejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco J. Brice\u00f1o Delgado El citomegalovirus (cmv) induce en el receptor de un trasplante de organos un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,141,10,973,597],"tags":[23772,2043,43888,39184,2326,1935],"class_list":["post-133308","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-cirugia","category-cirugia-de-trasplantes","category-cordoba","category-microbiologia-clinica","tag-carlos-lumbreras-bermejo","tag-carlos-pera-madrazo","tag-evaristo-varo-perez","tag-francisco-j-briceno-delgado","tag-javier-lopez-pujol","tag-pedro-sanchez-guijo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=133308"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133308\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=133308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=133308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=133308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}