{"id":133309,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-respuesta-linfoproliferativa-inducida-por-antigeno-de-cmv\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"caracterizacion-de-la-respuesta-linfoproliferativa-inducida-por-antigeno-de-cmv","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-de-la-respuesta-linfoproliferativa-inducida-por-antigeno-de-cmv\/","title":{"rendered":"Caracterizacion de la respuesta linfoproliferativa inducida por antigeno de cmv."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juliana Caballero Gueto <\/strong><\/h2>\n<p>Hipotetizamos para el acv un efecto modulador sobre las celulas del sistema inmune, impidiendo el paso de infeccion a enfermedad. En un ensayo clinico evaluamos el efecto del acv, usado como profilaxis en transplantados hepaticos, sobre la enfermedad y la infeccion por cmv. En los ensayos experimentales evaluamos el efecto del acv sobre la respuesta linfoproliferativa inducida por ag de cmv, hsv, sarampion y pha, utilizando linfocitos de sujetos sanos seropositivos para estos virus. Las celulas fueron incubadas con los ags en presencia de acv durante 5 dias; la proliferacion linfocitaria se determino mediante la incorporacion de timidina (h3) y el fenotipo (cd3, cd4, cd8, cd14, cd19, cd56,alfa-beta y gamma-delta) mediante anticuerpos monoclonales (t ifd) y citometro de flujo. En el sobrenadante del cultivo y mediante elisa se determinaron il2, il4, tnfalfa, infgamma e icam1-s. Acv profilactico en transplantados hepaticos disminuyo la incidencia de enfermedad pero no de infeccion por cmv.  acv in vitro produjo una disminucion de la respuesta linfoproliferativa inducida por ag de cmv y hsv, pero no por ag de sarampion o por pha cmv y hsv indujeron una respuesta de celulas t, sobre todo a expensas de cd8, invirtiendo el cociente normal cd4\/cd8. Sarampion y pha indujeron una proliferacion equilibrada de todas las subpoblaciones sin alterar el cociente. Acv indujo una depresion de la respuesta excesiva de cd8 inducida por ag de cmv y hsv, restableciendo el cociente normal cd4\/cd8.  este farmaco tambien deprimio la produccion de il2, tnfalfa e icam1-s inducida por los mismos ag.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion de la respuesta linfoproliferativa inducida por antigeno de cmv.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion de la respuesta linfoproliferativa inducida por antigeno de cmv. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juliana Caballero Gueto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro S\u00e1nchez Guijo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Jim\u00e9nez Perep\u00e9rez <\/li>\n<li>Jer\u00f3nimo Pachon D\u00edaz (vocal)<\/li>\n<li>Juan  Bautista Gutierrez Aroca (vocal)<\/li>\n<li>Albert Pahisa Berga (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juliana Caballero Gueto Hipotetizamos para el acv un efecto modulador sobre las celulas del sistema inmune, impidiendo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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