{"id":133328,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/especificidad-mutagenica-de-agentes-alquilantes-monofuncionales-y-bifuncionales-papel-de-la-reparacion-del-dna\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"especificidad-mutagenica-de-agentes-alquilantes-monofuncionales-y-bifuncionales-papel-de-la-reparacion-del-dna","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/especificidad-mutagenica-de-agentes-alquilantes-monofuncionales-y-bifuncionales-papel-de-la-reparacion-del-dna\/","title":{"rendered":"Especificidad mutagenica de agentes alquilantes monofuncionales y bifuncionales. papel de la reparacion del dna."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Ferrezuelo Mu\u00f1oz <\/strong><\/h2>\n<p>En este trabajo se han usado 2 aproximaciones experimentales para el estudio de la mutagenicidad de diversos agentes alquilantes en e. Coli. Una ha sido la obtencion de curvas dosis-respuesta con el fin de evaluar la potencia mutagenica de los compuestos y el papel de la reparacion. La segunda aproximacion ha consistido en el analisis molecular de la secuencia nucleotidica del blanco genetico empleado para conocer la naturaleza y distribucion de los cambios producidos, lo que ha permitido evaluar la importancia de las lesiones implicadas en la mutagenesis y las especificidades de secuencia en la reaccion de los compuestos y en los mecanismos de reparacion.  la alquiltransferasa ogt y el sistema ner reparan los da\u00f1os inducidos por pnu y bnu. El aducto 06-alquilguanina es primordial en la mutagenesis de los agentes alquilantes empleados, los cuales difieren en la longitud de la cadena alquilica (pnu vs. Bnu) y en el caracter mono- (pnu y bnu) o bifuncional (ccnu y bcnu) de los grupos reactivos. Pnu y bnu reaccionaron de forma similar con el dna, mientras que ccnu lo hizo de forma distinta.  los mecanismos de reparacion muestran diferentes especificidades de secuencia frente a los distintos agentes utilizados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Especificidad mutagenica de agentes alquilantes monofuncionales y bifuncionales. papel de la reparacion del dna.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Especificidad mutagenica de agentes alquilantes monofuncionales y bifuncionales. papel de la reparacion del dna. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Ferrezuelo Mu\u00f1oz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Pueyo De La Cuesta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Lopez Barea <\/li>\n<li>Andr\u00e9s Aguilera L\u00f3pez (vocal)<\/li>\n<li> De Vidania Mu\u00f1oz Rosa (vocal)<\/li>\n<li>Eduardo De La Pe\u00f1a Torres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Ferrezuelo Mu\u00f1oz En este trabajo se han usado 2 aproximaciones experimentales para el estudio de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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