{"id":133396,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/seguimiento-molecular-de-pacientes-sometidos-a-trasplante-alogenico-de-medula-osea-por-leucemia-mieloide-cronica\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"seguimiento-molecular-de-pacientes-sometidos-a-trasplante-alogenico-de-medula-osea-por-leucemia-mieloide-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/seguimiento-molecular-de-pacientes-sometidos-a-trasplante-alogenico-de-medula-osea-por-leucemia-mieloide-cronica\/","title":{"rendered":"Seguimiento molecular de pacientes sometidos a trasplante alogenico de medula osea por leucemia mieloide cronica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Rom\u00e1n G\u00f3mez <\/strong><\/h2>\n<p>Se realiza un seguimiento del transcrito ber-abl por rt-pcr, reordenamiento del gen bcr por southern blot y del quimerismo hemopoyetico por pcr en 27 pacientes trasplantados con medula no manipulada de un hermano hla identico por leucemia mieloide cronica. 16 de los pacientes fueron persistentemente positivos para el bcr-abl, cuatro pacientes negativizaron el resultado a lo largo de la evolucion y siete fueron siempre negativos.  la persistente positividad se asocio a una elevada masa tumoral en el momento del trasplante y a la disminucion de la capacidad inmunologica del injerto. Todos los pacientes presentaban quimera completa excepto los dos pacientes que sufrieron recaidas en los que se detecto un quimerismo mixto 10 y 21 meses antes de la recidiva hematologica. Se concluye que la erradicacion completa de la clona tumoral no es condicion indispensable para considerar curada la enfermedad. Los pacientes que son continuamente positivos para el bcr-abl constituyen un grupo de elevado riesgo para la recaida en los que el analisis del quimerismo aporta informacion complementaria sobre su desenlace final tras el trasplante.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Seguimiento molecular de pacientes sometidos a trasplante alogenico de medula osea por leucemia mieloide cronica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Seguimiento molecular de pacientes sometidos a trasplante alogenico de medula osea por leucemia mieloide cronica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Rom\u00e1n G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Torres G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Jim\u00e9nez Perep\u00e9rez <\/li>\n<li>Alberto Gra\u00f1ena Batista (vocal)<\/li>\n<li>Rafael Solana Lara (vocal)<\/li>\n<li> Garc\u00eda Conde Bru Javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Rom\u00e1n G\u00f3mez Se realiza un seguimiento del transcrito ber-abl por rt-pcr, reordenamiento del gen bcr por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,973,218,195,139,156],"tags":[219,29697,11726,1614,36545,3760],"class_list":["post-133396","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cordoba","category-hematologia","category-hemopatologia","category-medicina-interna","category-patologia","tag-alberto-granena-batista","tag-antonio-torres-gomez","tag-garcia-conde-bru-javier","tag-jose-antonio-jimenez-pereperez","tag-jose-roman-gomez","tag-rafael-solana-lara"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=133396"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133396\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=133396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=133396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=133396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}