{"id":133548,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-anatomopatologicas-hepaticas-y-valor-de-la-timoestimulina-tp-1-en-la-restauracion-de-la-inmunidad-celular-en-la-rata-icterica-y-anergica\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"alteraciones-anatomopatologicas-hepaticas-y-valor-de-la-timoestimulina-tp-1-en-la-restauracion-de-la-inmunidad-celular-en-la-rata-icterica-y-anergica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-anatomopatologicas-hepaticas-y-valor-de-la-timoestimulina-tp-1-en-la-restauracion-de-la-inmunidad-celular-en-la-rata-icterica-y-anergica\/","title":{"rendered":"Alteraciones anatomopatologicas hepaticas y valor de la timoestimulina tp-1 en la restauracion de la inmunidad celular en la rata icterica y anergica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Paulos Gomez Ana M. <\/strong><\/h2>\n<p>La colestasis es una situacion clinica que implica alto riesgo de complicaciones septicas. Se cree que es como consecuencia de una disminucion del estado de inmunidad celular. El trabajo de investigacion se basa en la creacion de un estado de ictericia en ratas de forma artificial, mediante la ligadura del coledoco.Con ello objetivamos cambios anatomopatologicos microscopicos profundos que se inician en el higado con edema periportal y proliferacion ductal hasta objetivar en la sexta semana postligadur, fibrosis y cirrosis. &#8211; La ligadura y seccion del coledoco en ratas inmunocompetentes trae consigo una disminucion del estado de inmunidad celular medida con test cutaneos de hipersensibilidad retardada. A estas ratas ictericas y anergicas se les administra timoestimulina tp-1 intraperitoneal a dosis de 0,4 ml\/kg\/dia durante una semana y se observa una recuperacion de la respuesta a los test cutaneos de hipersensibilidad retardada que estan consensuados como metodo de medicion de inmunidad celular. &#8211; Tambien se observa un incremento estadisticamente significativo de los niveles de linfocitos t colaboradores (cd4) con respecto al grupo control que no recibio tp-1 siendo p&lt;0,03.- Se observa tambien un incremento de los niveles de linfocitos t totales.La timoestimulina modifica el estado de inmunidad. &#8211; Los resultados obtenidos con este trabajo de investigacion coincidentes con lo publicado en la literatura, justificaria la continuacion de las investigaciones con timoestimulina en el campo de la cirugia en el paciente con ictericia obstructiva.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones anatomopatologicas hepaticas y valor de la timoestimulina tp-1 en la restauracion de la inmunidad celular en la rata icterica y anergica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones anatomopatologicas hepaticas y valor de la timoestimulina tp-1 en la restauracion de la inmunidad celular en la rata icterica y anergica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Paulos Gomez Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Ca\u00ednzos Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Puente Dom\u00ednguez Jos\u00e9 Luis <\/li>\n<li>Enrique Martinez Rodriguez (vocal)<\/li>\n<li>Joaqu\u00edn Potel Lesquereux (vocal)<\/li>\n<li>Juan  Carlos Garc\u00eda-valdecasas Salgado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paulos Gomez Ana M. La colestasis es una situacion clinica que implica alto riesgo de complicaciones septicas. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,1279,977],"tags":[8848,2044,1155,9753,247548,17778],"class_list":["post-133548","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","category-santiago-de-compostela","tag-enrique-Martinez-rodriguez","tag-joaquin-potel-lesquereux","tag-juan-carlos-garcia-valdecasas-salgado","tag-miguel-angel-cainzos-fernandez","tag-paulos-gomez-ana-m","tag-puente-dominguez-jose-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=133548"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133548\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=133548"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=133548"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=133548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}