{"id":133581,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-derivados-butirofenonicos-como-potenciales-neurolepticos\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-farmacologico-de-derivados-butirofenonicos-como-potenciales-neurolepticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-derivados-butirofenonicos-como-potenciales-neurolepticos\/","title":{"rendered":"Estudio farmacologico de derivados butirofenonicos como potenciales neurolepticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elizabeth Rosa Barreiro <\/strong><\/h2>\n<p>En esta memoria experimental se estudio la potencial actividad neuroleptica de nuevos derivados butirofenonicos, los cuales constan de un fragmento butirofenonico flexible, similar al del haloperidol, con la diferencia de que el nitrogeno terciario esta incluido en un anillo de piperazina, en lugar de piperidina y al que se le han incorporado diversas etilbenzocicloalcanonas. Como farmacos de referencia se utilizaron el haloperidol, prototipo de los antipsicoticos tipicos y la clozapina, prototipo de los atipicos. En los experimentos \u00abin vitro\u00bb, las moleculas exhibieron menor afinidad por los receptores d1, d2 y 5-ht2a que los farmacos de referencia, excepto con respecto a la clozapina en la fijacion a receptores d2.  en los experimentos \u00abex vivo\u00bb se cuantifico la concentracion de dopamina y sus metabolitos (dopac y hva), no modificandose los valores de dopamina, excepto con la clozapina a la dosis de 20 mg\/kg y donde las moleculas incrementaron la concentracion de sus metabolitos de manera menos potente que el haloperidol y la clozapina. Los experimentos \u00abin vivo\u00bb se dividieron en: a) predictivos de efecto antipsicotico, en los cuales las moleculas fueron menos potentes, en general, que los farmacos de referencia; b) predictivos de efectos extrapiramidales, donde las mismas afectaron la via nigroestriatal, al igual que el haloperidol y a diferencia de la clozapina; c) complementarios. De todos los resultados obtenidos se desprende que la incorporacion al farmacoforo butirofenonico flexible de un anillo de piperazina que porta en el nitrogeno de la posicion 4, un sustituyente etilbenzocicloalcanona supone una perdida significativa de afinidad por los receptores estudiados, lo cual se correlaciona con su menor potencia antipsicotica y ademas, se acompa\u00f1a de una relativa elevada capacidad para inducir efectos extrapiramidales no deseados, por lo que estas moleculas se incluyen en el grupo de los antipsicoticos tipicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacologico de derivados butirofenonicos como potenciales neurolepticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacologico de derivados butirofenonicos como potenciales neurolepticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elizabeth Rosa Barreiro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Isabel Cadavid Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Calleja Suarez <\/li>\n<li>Enrique Ravi\u00f1a Rubira (vocal)<\/li>\n<li>Alfonso Velasco Martin (vocal)<\/li>\n<li> Lopez De Ceballos Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elizabeth Rosa Barreiro En esta memoria experimental se estudio la potencial actividad neuroleptica de nuevos derivados butirofenonicos, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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