{"id":133674,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-y-aspectos-inmunologicos-del-tratamiento-con-gammaglobulinas-intravenosas-a-dosis-elevadas-en-gestantes-con-isoinmunizacion-rh\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"valoracion-y-aspectos-inmunologicos-del-tratamiento-con-gammaglobulinas-intravenosas-a-dosis-elevadas-en-gestantes-con-isoinmunizacion-rh","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valoracion-y-aspectos-inmunologicos-del-tratamiento-con-gammaglobulinas-intravenosas-a-dosis-elevadas-en-gestantes-con-isoinmunizacion-rh\/","title":{"rendered":"Valoracion y aspectos inmunologicos del tratamiento con gammaglobulinas intravenosas a dosis elevadas en gestantes con isoinmunizacion rh."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Cardona Contreras <\/strong><\/h2>\n<p>Introduccion: la isoinmunizaci\u00f3n rh (isorh) produce hem\u00f3lisis en los fetos rh + causando la enfermedad hemol\u00edtica perinatal (ehp). Esta contin\u00faa contribuyendo notablemente a la morbimortalidad perinatal. Los m\u00e9todos de control y tratamiento invasivos pueden empeorar el cuadro, por eso en los \u00faltimos a\u00f1os se han buscado tratamientos no invasivos entre los que se encuentran las inmunoglobulinas intravenosas (igiv).  objetivos: 1.- Revisar la epidemiolog\u00eda y cl\u00ednica, curso de la gestaci\u00f3n, parto y resultados perinatales en la isorh. 2.- Examinar el comportamiento de algunos par\u00e1metros inmunol\u00f3gicos para intentar explicar la base patog\u00e9nica que se produce en las pacientes con isorh frente a las gestantes normales. 3.- Estudiar los posibles cambios de los par\u00e1metros inmunol\u00f3gicos tras el tto. Con igiv, buscando hallar una explicaci\u00f3n al mecanismo de acci\u00f3n de las igiv en esta patolog\u00eda.  material y metodos: se revisan todos los casos de isorh atendidos en el hospital \u00abvirgen de las nieves\u00bb de granada entre 1984 y 1995, comparando los tratamientos empleados (cl\u00e1sico frente a igiv), y los par\u00e1metros inmunol\u00f3gicos en gestantes isoinmunizadas antes y despu\u00e9s del tto. Con igiv frente a un grupo control de gestantes no isoinmunizadas.  resultados: la incidencia durante los a\u00f1os de estudio (1984-1995) no vari\u00f3 significativamente. La administraci\u00f3n de igiv evita el ascenso natural de los t\u00edtulos del test de coombs indirecto, reduce la necesidad de exanguinotransfusi\u00f3n, transfusi\u00f3n sangu\u00ednea y los valores de bilirrubina total e indirecta en los reci\u00e9n nacidos, lo que produce una disminuci\u00f3n del tiempo de ingreso en la unidad neonatal. No se ha hallado que el sistema del complemento juegue un papel clave en la fisiopatolog\u00eda de la iso rh. La isorh provoca un estado de inmunoactivaci\u00f3n generalizado (aumento de linfocitos t dr(+) y linfocitos b cd5(+)) sin provocar un desequilibrio en la regulaci\u00f3n inmunitaria.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoracion y aspectos inmunologicos del tratamiento con gammaglobulinas intravenosas a dosis elevadas en gestantes con isoinmunizacion rh.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoracion y aspectos inmunologicos del tratamiento con gammaglobulinas intravenosas a dosis elevadas en gestantes con isoinmunizacion rh. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Cardona Contreras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco J. Gonz\u00e1lez G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Navarrete Lopez-cozar <\/li>\n<li>Antonio Gonzalez Gonzalez (vocal)<\/li>\n<li>Alfonso Herruzo Nalda (vocal)<\/li>\n<li>Emilio Doblar\u00e9 Castellano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Cardona Contreras Introduccion: la isoinmunizaci\u00f3n rh (isorh) produce hem\u00f3lisis en los fetos rh + causando la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,35,9,135,4667,1737],"tags":[3487,4193,3764,4419,192607,4194],"class_list":["post-133674","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-ginecologia","category-inmunizacion","category-inmunologia","tag-alfonso-herruzo-nalda","tag-antonio-gonzalez-gonzalez","tag-emilio-doblare-castellano","tag-francisco-j-gonzalez-gomez","tag-jesus-cardona-contreras","tag-luis-navarrete-lopez-cozar"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=133674"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/133674\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=133674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=133674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=133674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}