{"id":13370,"date":"2018-03-09T08:59:37","date_gmt":"2018-03-09T08:59:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/infeccion-por-el-virus-tt-en-ha%c2%adgado-y-celulas-mononucleares-de-sangre-periferica-hepatotropismo-y-linfotropismo\/"},"modified":"2018-03-09T08:59:37","modified_gmt":"2018-03-09T08:59:37","slug":"infeccion-por-el-virus-tt-en-ha%c2%adgado-y-celulas-mononucleares-de-sangre-periferica-hepatotropismo-y-linfotropismo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/infeccion-por-el-virus-tt-en-ha%c2%adgado-y-celulas-mononucleares-de-sangre-periferica-hepatotropismo-y-linfotropismo\/","title":{"rendered":"Infecci\u00f3n por el virus tt en h\u00edgado y c\u00e9lulas mononucleares de sangre perif\u00e9rica hepatotropismo y linfotropismo"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mariscal Sancho Luisa Fernanda <\/strong><\/h2>\n<p>El virus tt (ttv) fue identificado en 1997 a partir del suero de un paciente con una hepatitis aguda postransfuncional. Se trata de un virus cuyo genoma es adn monocatenario, circular y de polaridad negativa con una longitud aproximada de 3,8 kb. Por sus caracter\u00edsticas gen\u00f3micas se propuso que el ttv replica siguiendo el mecanismo del \u00abc\u00edrculo rodante\u00bb.  en la presente tesis doctoral se ha determinado la presencia del ttv en suero, h\u00edgado y c\u00e9lulas mononucleares de sangre perif\u00e9rica (cmsp) de pacientes con hepatitis cr\u00f3nica, demostr\u00e1ndose la infecci\u00f3n por dicho virus en h\u00edgado y cmsp mediante pcr e hibridaci\u00f3n in situ y por tanto que se trata de un virus hepatotropo y linfotropo. Por otra parte, se ha establecido un sistema de cultivo e infecci\u00f3n in vitro por ttv de las cmsp mediante el cual se ha demostrado que las c\u00e9lulas son infectadas por el virus de forma similiar a como ocurre in vivo. Sin embargo, para que se lleve a cabo la replicaci\u00f3n del virus es necesario que las cmsp est\u00e9n estimuladas. en estas c\u00e9lulas se ha demostrado la presencia de intermediarios replicativos de adn de cadena doble, por lo que se puede afirmar que el ttv replica siguiendo el mecanismo del \u00abc\u00edrculo rodante\u00bb y mediante el modelo sim\u00e9trico. adem\u00e1s, tambi\u00e9n se ha detectado la presencia de arn mensajero del ttv y se ha demostrado que las part\u00edculas virales recuperadas de cultivos infectados in vitro son capaces de infectar nuevas c\u00e9lulas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Infecci\u00f3n por el virus tt en h\u00edgado y c\u00e9lulas mononucleares de sangre perif\u00e9rica hepatotropismo y linfotropismo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Infecci\u00f3n por el virus tt en h\u00edgado y c\u00e9lulas mononucleares de sangre perif\u00e9rica hepatotropismo y linfotropismo <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mariscal Sancho Luisa Fernanda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Carre\u00f1o Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: yolanda (secretario) Revilla novella <\/li>\n<li>Jos\u00e9 Luis Bella sombria (vocal)<\/li>\n<li>Javier Bartolom\u00e9 nebreda (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mariscal Sancho Luisa Fernanda El virus tt (ttv) fue identificado en 1997 a partir del suero de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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