{"id":13372,"date":"2018-03-09T08:59:37","date_gmt":"2018-03-09T08:59:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-evasion-del-sistema-inmune-por-el-virus-del-sarampion\/"},"modified":"2018-03-09T08:59:37","modified_gmt":"2018-03-09T08:59:37","slug":"mecanismos-de-evasion-del-sistema-inmune-por-el-virus-del-sarampion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/mecanismos-de-evasion-del-sistema-inmune-por-el-virus-del-sarampion\/","title":{"rendered":"Mecanismos de evasi\u00f3n del sistema inmune por el virus del sarampi\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paloma Borrajo Lit\u00f3n <\/strong><\/h2>\n<p>El virus del sarampi\u00f3n (vs) es un pat\u00f3geno altamente contagioso caracterizado por:  1,- originar una infecci\u00f3n sist\u00e9mica multiorg\u00e1nica.  2,- inducir una inmunosupresi\u00f3n transitoria.  3,- ser capaz de persistir en el organismo, siendo la persistencia del vs en el sistema nervioso central responsable de la aparici\u00f3n de dos enfermedades neurodegenerativas letales (pes y mibe).  estas tres caracter\u00edsticas hicieron que nos pregunt\u00e1semos si el vs pudiera haber desarrollado estrategias de evasi\u00f3n frente al sistema inmune (si) celular, campo en el que no se contaban con estudios previos.  1,- describimos por primera vez que la infecci\u00f3n por vs induce resistencia a la \u00e1cci\u00f3n del ifn-alfa al interceptar en la cascada de se\u00f1alizaci\u00f3n del ifn-alfa. Hemos observado que la interrupci\u00f3n de la se\u00f1al es debida a una inhibici\u00f3n de la expresi\u00f3n de las prote\u00ednas quinasas jak1 y tyk2 en las c\u00e9lulas infectadas, encontr\u00e1ndose inhbida la fosforilaci\u00f3n de la prote\u00edna stat1 en respueta al tratamiento celular con ifn-alfa y la formaci\u00f3n del complejo transcripcional isgf3. Asimismo se ha observado una inhibici\u00f3n de la translocaci\u00f3n de las prote\u00edna p48 al n\u00facleo. Ambos efectos impiden la inducci\u00f3n de la transcripci\u00f3n de los genes efectores de la acci\u00f3n del ifn-alfa. Por otro lado se ha observado una inhibici\u00f3n de la producci\u00f3n de ifn-alfa en infecciones l\u00edticas y persistentes por los aislados primarios del vs, al contrario de lo observado en las infecciones por la cepa vacunal edmonston, cuya infecci\u00f3n induce la secrecci\u00f3n continuada de ifn-alfa con actividad antiproliferativa y antiviral.  2,- se describe en este trabajo una inhibici\u00f3n de la secreci\u00f3n de iga e ige en la infecci\u00f3n l\u00edtica y persistente por vs. Este efecto es debido a defectos en la maduraci\u00f3n de iga. En estas c\u00e9lulas fue detectada una uni\u00f3n estable entre la glicoprote\u00edna viral h con los chaperones moleculares bip y grp94, as\u00ed como una estimulaci\u00f3n d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de evasi\u00f3n del sistema inmune por el virus del sarampi\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de evasi\u00f3n del sistema inmune por el virus del sarampi\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paloma Borrajo Lit\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Fern\u00e1ndez Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel (secretario) L\u00f3pez carrascosa <\/li>\n<li>enrique Tabares lopez (vocal)<\/li>\n<li>Juan Ortin monton (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paloma Borrajo Lit\u00f3n El virus del sarampi\u00f3n (vs) es un pat\u00f3geno altamente contagioso caracterizado por: 1,- originar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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