{"id":133725,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismo-de-genes-del-mhc-en-la-espondilitis-anquilosante\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"polimorfismo-de-genes-del-mhc-en-la-espondilitis-anquilosante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismo-de-genes-del-mhc-en-la-espondilitis-anquilosante\/","title":{"rendered":"Polimorfismo de genes del mhc en la espondilitis anquilosante."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Fraile Ramos <\/strong><\/h2>\n<p>La espondilitis anquilosante (ea) es una patolog\u00eda relativamente frecuente, que presenta una de las asociaciones m\u00e1s fuertes con especificidades hla, en concreto con el ant\u00edgeno hla-b27. Existen evidencias que llevan a pensar que otros factores gen\u00e9ticos distintos a hla-b27 est\u00e1n implicados en la patog\u00e9nesis de la ea.  debido a su localizaci\u00f3n en el mhc y a su funci\u00f3n en la presentaci\u00f3n antig\u00e9nica y en la respuesta inmune, los genes lmp, tap, hsp70 y tnf son ideales candidatos como factores que podr\u00edan contribuir en la susceptibilidad a la ea. El objetivo de nuestro trabajo fue analizar la posible influencia del polimorfismo de genes implicados en la respuesta inmune (hla-b27, tap, lmp, hsp70 y tnf) en la susceptibilidad a la espondilitis anquilosante.  adem\u00e1s del dise\u00f1o y desarrollo de nuevos m\u00e9todos para el tipaje de estos genes. Se seleccionaron 57 pacientes diagnosticados de ea, 35 controles b*27+ y 102 controles seleccionados al azar, sobre los cuales se llevo a cabo el estudio del polimorfismo de estos genes. Encontramos que: 1) los alelos b*2705, b*2702 y b*2707 estaban asociados a la ea, siendo la primera vez que se describe b*2707 en poblaci\u00f3n caucasoide; 2) el gen lmp7 influye, conjuntamente con b*27, en la susceptibilidad a la ea; 3) los genes lmp2, tap, hsp70 y tnf no desempe\u00f1an un papel relevante en la susceptibilidad a la ea y 4) la estrategia basada en pcr-rflp+acrs ha resultado un m\u00e9todo adecuado para el an\u00e1lisis del polimorfismo conocido de genes del mhc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismo de genes del mhc en la espondilitis anquilosante.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismo de genes del mhc en la espondilitis anquilosante. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Fraile Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Martin Iba\u00f1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio L\u00f3pez De Castro <\/li>\n<li>Antonio Alonso Ortiz (vocal)<\/li>\n<li>Marta Vives Pi (vocal)<\/li>\n<li> Vilches Ruiz Blas Carlos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Fraile Ramos La espondilitis anquilosante (ea) es una patolog\u00eda relativamente frecuente, que presenta una de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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