{"id":13394,"date":"2018-03-09T08:59:39","date_gmt":"2018-03-09T08:59:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-cardiovasculares-dela-genistea%c2%adna-en-el-mdoelo-de-shock-septico-de-rata-inducido-por-lipopolisacarido\/"},"modified":"2018-03-09T08:59:39","modified_gmt":"2018-03-09T08:59:39","slug":"efectos-cardiovasculares-dela-genistea%c2%adna-en-el-mdoelo-de-shock-septico-de-rata-inducido-por-lipopolisacarido","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-cardiovasculares-dela-genistea%c2%adna-en-el-mdoelo-de-shock-septico-de-rata-inducido-por-lipopolisacarido\/","title":{"rendered":"Efectos cardiovasculares dela geniste\u00edna, en el mdoelo de shock s\u00e9ptico de rata inducido por lipopolisac\u00e1rido"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Almudena Bermejo G\u00f3mez <\/strong><\/h2>\n<p>El shock s\u00e9ptico es una de las m\u00e1s importantes complicaciones producidas por una infecci\u00f3n bacteriana severa de agentes gram (-), a las cuales pertenece al lipopolisac\u00e1rido lps, principal agente responsable, y gram (+). \u00e9Ste se caracteriza incialmente por una respuesta intravascular inflamatoria que desarrolla hipotensi\u00f3n, fiebre, inadecuada perfusi\u00f3n de los tejidos y coagulaci\u00f3n intravascular diseminada, todo ello conduce al s\u00edndrome de disfuci\u00f3n org\u00e1ncia m\u00faltiple y a la muerte. La inhibici\u00f3n de las reacciones inmunoinflamatorias con antibi\u00f3ticos tiene un \u00e9xito terap\u00e9utico limitado, sin embrago, si se acompa\u00f1a de la prevenci\u00f3n de las reacciones circulatorias que se manifiestan los primeros estad\u00edos del s\u00edndrome s\u00e9ptico, en especial la ca\u00edda de la resistencia perif\u00e9rica, puede disminuir el grado de mortalidad.  los estudios realizados en modelos animales y en pacientes con septicemia demuestran una p\u00e9rdida del tono vascular, consecuencia de la superproducci\u00f3n de \u00f3xido n\u00edtrico no en la pared vascular debido a la inducci\u00f3n de la nosi. no obstante, la aplicaci\u00f3n terap\u00e9utica del bloqueo global de la v\u00eda del no, no est\u00e1 unido a una mejora ya que produce efectos nocivos. La activaci\u00f3n de tirosinkinasas ha sido implicada en la se\u00f1al de transducci\u00f3n provocada por endotoxina que conduce a la inducci\u00f3n de la nosi.As\u00ed, los inhibidores de tirosinkinasas, entre los que se encuentra la geniste\u00edna, resultan beneficiosos en el shock s\u00e9ptico.  las conclusiones obtenidas en esta tesis doctoral han sido las siguientes:  1,- la endotoxemia inducida por la inyecci\u00f3n de lps (10 mg\/kg) en rata rogina hipotensi\u00f3n, acompa\u00f1da de alteraciones en la reactividad vascular de preparaciones ex vivo (aorta tor\u00e1cica y lecho mesent\u00e9rico), tales como:  a,- disfunci\u00f3n endotelial puesta de manifiesto en la hiporrespuesta a acetilcolina.  b,- reducci\u00f3n de la respuesta vasoconstrictora de la noradrenalina.  2,- estas alteracion<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos cardiovasculares dela geniste\u00edna, en el mdoelo de shock s\u00e9ptico de rata inducido por lipopolisac\u00e1rido<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos cardiovasculares dela geniste\u00edna, en el mdoelo de shock s\u00e9ptico de rata inducido por lipopolisac\u00e1rido <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Almudena Bermejo G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Manuel Duarte P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Jim\u00e9nez mart\u00edn <\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Calleja suarez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Almudena Bermejo G\u00f3mez El shock s\u00e9ptico es una de las m\u00e1s importantes complicaciones producidas por una infecci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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