{"id":13396,"date":"2018-03-09T08:59:39","date_gmt":"2018-03-09T08:59:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/metabolismo-y-secrecion-de-acidos-biliares-en-rtas-con-hipercolesterolemia-modificaciones-inducidas-por-la-adicion-de-beta-ciclodextrina\/"},"modified":"2018-03-09T08:59:39","modified_gmt":"2018-03-09T08:59:39","slug":"metabolismo-y-secrecion-de-acidos-biliares-en-rtas-con-hipercolesterolemia-modificaciones-inducidas-por-la-adicion-de-beta-ciclodextrina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/metabolismo-y-secrecion-de-acidos-biliares-en-rtas-con-hipercolesterolemia-modificaciones-inducidas-por-la-adicion-de-beta-ciclodextrina\/","title":{"rendered":"Metabolismo y secreci\u00f3n de \u00e1cidos biliares en rtas con hipercolesterolemia: modificaciones inducidas por la adici\u00f3n de beta-ciclodextrina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Victoria Garc\u00eda Mediavilla <\/strong><\/h2>\n<p>La beta-ciclodextrina (beta-cd) es un compuesto que forma complejos de inclusi\u00f3n con una gran variedad de mol\u00e9culas, especialmente con los \u00e1cidos biliares y los esteroles.  en este estudio hemos investigado el efecto de la beta-cd sobre el metabolismo y la secreci\u00f3n de \u00e1cidos biliares en ratas hipercolesterol\u00e9micas.  para ello, se utilizaron ratas macho de raza wistar, repartidas en cuatro grupos que recibieron durante 6 semanas: dieta control, dieta con un 2% de colesterol, dieta con un 2% de colesterol y un 2,5% de beta-cd, y dieta con un 2% de colestero, y un 5% de beta-cd.  la dieta enriquecida con colesterol indujo hepatomegalia que estuvo acompa\u00f1ada por una menor secreci\u00f3n biliar de colesterol, fosfol\u00edpidos y \u00e1cidos biliares.  la adici\u00f3n beta-cd en la dieta normaliz\u00f3 la secreci\u00f3n biliar de l\u00edpidos. adem\u00e1s, cuando se compar\u00f3 con la dieta con colesterol a\u00f1adido, la beta-cd disminuy\u00f3 significativamente la concentraci\u00f3n plasm\u00e1tica de fosfol\u00edpidos y la relaci\u00f3n molar hep\u00e1tica de colesterol libre\/total, increment\u00f3 la excreci\u00f3n fecal de \u00e1cidos biliares y aument\u00f3 la actividad colesterol 7alfa-hidroxilasa y la cantidad de su arnm. La beta-cd al 5% tambi\u00e9n redujo la concentraci\u00f3n plasm\u00e1tica de triglic\u00e9ridos. La adici\u00f3n de beta-cd en la dieta no fuez capaz de revertir el efecto causado por el colesterol sobre la actividad hmg-coa reductasa hep\u00e1tica, si bien indujo la expresi\u00f3n de su gen.  en conclusi\u00f3n, la adici\u00f3n de beta-cd a una diera enriquecida con colesterol provca una disminuci\u00f3n de l\u00edpidos biliares, aumentando la s\u00edntesis y la excreci\u00f3n de \u00e1cidos biliares y normalizando la secreci\u00f3n biliar de l\u00edpidos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Metabolismo y secreci\u00f3n de \u00e1cidos biliares en rtas con hipercolesterolemia: modificaciones inducidas por la adici\u00f3n de beta-ciclodextrina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Metabolismo y secreci\u00f3n de \u00e1cidos biliares en rtas con hipercolesterolemia: modificaciones inducidas por la adici\u00f3n de beta-ciclodextrina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Victoria Garc\u00eda Mediavilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Gonz\u00e1lez Gallego<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alejandro Esteller  perez <\/li>\n<li>Mar\u00eda  Jes\u00fas Tu\u00f1\u00f3n gonz\u00e1lez (vocal)<\/li>\n<li>carmen Villares Garc\u00eda (vocal)<\/li>\n<li>sonia S\u00e1nchez campos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Victoria Garc\u00eda Mediavilla La beta-ciclodextrina (beta-cd) es un compuesto que forma complejos de inclusi\u00f3n con una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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