{"id":13403,"date":"2018-03-09T08:59:40","date_gmt":"2018-03-09T08:59:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nevus-displasico-gradacion-de-la-atipia-y-correlacion-de-la-atipia-con-marcadores-de-proliferacion-y-de-migracion-celular\/"},"modified":"2018-03-09T08:59:40","modified_gmt":"2018-03-09T08:59:40","slug":"nevus-displasico-gradacion-de-la-atipia-y-correlacion-de-la-atipia-con-marcadores-de-proliferacion-y-de-migracion-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nevus-displasico-gradacion-de-la-atipia-y-correlacion-de-la-atipia-con-marcadores-de-proliferacion-y-de-migracion-celular\/","title":{"rendered":"Nevus displasico: gradacion de la atipia y correlacion de la atipia con marcadores de proliferacion y de migracion celular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Arumi Uria <\/strong><\/h2>\n<p>El nevus displ\u00e1sico (nd), factor de riesgo de melanoma maligno, ha sido fuente de controversia en diferentes sentidos desde su descripci\u00f3n, el nombre asignado, los criterios cl\u00ednicos e histol\u00f3gicos que la caracterizan hasta la gradaci\u00f3n de los mismos en tres grados de atipia: leve, moderado y severo.  se ha evaluado en primer lugar si el grado de atipia de los nd tiene alguna relaci\u00f3n con el riesgo de padecer melanoma mediante un estudio de datos clinicos y en segundo lugar, buscar un marcador que permita realizar una clasificaci\u00f3n del grado de atipia de los nevus displ\u00e1sicos basada en criterios objetivos mediante el estudio de la expresi\u00f3n del marcador de proliferaci\u00f3n ki-67 y el marcador de migraci\u00f3n chat(acetil-colina transferasa).  en la primera parte del estudio se revisaron los informes de 20275 nevus recibidos entre 1989 y 1996, constat\u00e1ndose que 6275 eran nd que pertenecian a 4481 pacientes. Los pacientes fueron clasificados con respecto a su lesi\u00f3n con mayor grado de atipia y se revis\u00f3 sus datos cl\u00ednicos con respecto a la historia de melanoma. Se calcul\u00f3 la odds ratio (or) como medida de asociaci\u00f3n entre los grados de atipia de los nd e historia de melanoma. En la segunda parte del estudio se realiz\u00f3 estudio inmunohistoquimico con doble marcaje para hmb-45 y ki-67 en 36 nd con atipia leve, 36 nd con atipia moderada, 36 nd con atipia severa, 18 nevus melanoc\u00edticos benignos (nmb) y 18 melanomas maligos in-situ, evalu\u00e1ndose la proporci\u00f3n de c\u00e9lulas melanoc\u00edticas de la uni\u00f3n dermo-epid\u00e9rmica positivas para ki-67. Asi mismo se realiz\u00f3 estudio inmunohistoqu\u00edmico para chat en 30 nd con atipia leve, 30 con atipia moderada y 30 con atipia severa.  los resultados pusieron de manifiesto que 2504 pacientes presentaban nd con atipia leve como nevus con mayor grado de atipia, 1657 nd con atipia moderada y 320 nd con atipia severa. La revisi\u00f3n de sus datos clinicos puso de manifiesto que 142 pacientes del grupo de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nevus displasico: gradacion de la atipia y correlacion de la atipia con marcadores de proliferacion y de migracion celular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nevus displasico: gradacion de la atipia y correlacion de la atipia con marcadores de proliferacion y de migracion celular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Arumi Uria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Barranco Sanz Luis Carlos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: sergio Serrano figueras <\/li>\n<li>Jos\u00e9 Mar\u00eda Corominas torres (vocal)<\/li>\n<li>jeronimo Forteza vla (vocal)<\/li>\n<li>ramon Mar\u00eda Pujol vallverdu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Arumi Uria El nevus displ\u00e1sico (nd), factor de riesgo de melanoma maligno, ha sido fuente de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1027,156],"tags":[43529,43531,43530,43528,43532,2939],"class_list":["post-13403","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-oncologia","category-patologia","tag-barranco-sanz-luis-carlos","tag-jeronimo-forteza-vla","tag-jose-maria-corominas-torres","tag-montserrat-arumi-uria","tag-ramon-maria-pujol-vallverdu","tag-sergio-serrano-figueras"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13403"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13403\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}