{"id":13406,"date":"2018-03-09T08:59:40","date_gmt":"2018-03-09T08:59:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-y-estructura-funcion-de-la-neurostatina-y-moduladores-gicolipa%c2%addicos-de-la-division-de-la-astrocitomas\/"},"modified":"2018-03-09T08:59:40","modified_gmt":"2018-03-09T08:59:40","slug":"actividad-y-estructura-funcion-de-la-neurostatina-y-moduladores-gicolipa%c2%addicos-de-la-division-de-la-astrocitomas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/actividad-y-estructura-funcion-de-la-neurostatina-y-moduladores-gicolipa%c2%addicos-de-la-division-de-la-astrocitomas\/","title":{"rendered":"Actividad y estructura-funci\u00f3n de la neurostatina. y moduladores gicolip\u00eddicos de la divisi\u00f3n de la astrocitomas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lorenzo Romero Ram\u00edrez <\/strong><\/h2>\n<p>La neurostatina se ha descrito como un inhibidor de la divisi\u00f3n de astroblastos y c\u00e9lulas tumorales de origen astroglial presente en extractos de cerebro normal de diferentes mam\u00edferos. Mediante diferentes t\u00e9cnicas de resonancia y bioqu\u00edmicas se caracteriz\u00f3 como el gangli\u00f3sido gd1b con una o-acetilaci\u00f3n en su si\u00e1lico terminal.  en este estudio, se ha caracterizado la o-acetilaci\u00f3n de la neurostatina en la posici\u00f3n 9 de su si\u00e1lico terminal, as\u00ed como las regiones moleculares de la neurostatina importantes en la inhibici\u00f3n de la proliferaci\u00f3n inducida por los mit\u00f3genos egf y pdgf-b en l\u00edneas celulares de astrocitoma humano. la o-acetilaci\u00f3n en la posici\u00f3n 9 del \u00e1cido si\u00e1lico juega un papel esencial en la actividad de la neurostatina y de otros gangli\u00f3sidos o-acetilados, convertiendo gangli\u00f3sidos con capacidad mitog\u00e9nica en sustancias inhibidoras. la p\u00e9rdida de la estructura galactosil-n-acetil-galactosaminil en la neurostatina reduce 8 y 16 veces su actividad inhibidora dependiendo del polip\u00e9ptido mitog\u00e9nico ensayado. Adem\u00e1s, la p\u00e9rdida de un si\u00e1lico de la neurostatina aunque el si\u00e1lico restante est\u00e9 o-acetilado, reduce su actividad m\u00e1s de 20 veces. La actividad inhibidora de la estructura galactosil-n-acetil-glactosaminil requiere la participaci\u00f3n de los dos si\u00e1licos unidos consecutivamente, estando el si\u00e1lico terminal o-acetilado. La estructura galactosil-n-acetil-galactosaminil interaccionar\u00eda con los si\u00e1licos, dejando expuesta el si\u00e1lico o-acetilado terminal y la galactosa terminal, por donde probablemente la neurostatina interaccione con su receptor.  la neurostatina reduce la expresi\u00f3n de la ciclina d1 y de prb1 y aumenta la expresi\u00f3n de los inhibidores de ciclo p21 waf1\/cip1 y p27 kip1, provocando la parada del ciclo celular probablemente en la fase g1. Adem\u00e1s, la neurostatina induce en la l\u00ednea de astrocitoma humano u-373 cierto grado de diferenciaci\u00f3n celular, porque aumenta la expresi\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad y estructura-funci\u00f3n de la neurostatina. y moduladores gicolip\u00eddicos de la divisi\u00f3n de la astrocitomas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad y estructura-funci\u00f3n de la neurostatina. y moduladores gicolip\u00eddicos de la divisi\u00f3n de la astrocitomas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lorenzo Romero Ram\u00edrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Nieto Sampedro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jorgina Satr\u00fastegui gil-delgado <\/li>\n<li>teresa D\u00edaz maurino (vocal)<\/li>\n<li>amparo Cano garcia (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Frade l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorenzo Romero Ram\u00edrez La neurostatina se ha descrito como un inhibidor de la divisi\u00f3n de astroblastos y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,160,115,35,9,965,1027,156,17],"tags":[24375,6755,29768,43539,13725,43540],"class_list":["post-13406","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-ciencias-medicas","category-neuropatologia","category-oncologia","category-patologia","category-quimica","tag-amparo-cano-garcia","tag-jorgina-satrustegui-gil-delgado","tag-jose-maria-frade-lopez","tag-lorenzo-romero-ramirez","tag-manuel-nieto-sampedro","tag-teresa-diaz-maurino"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13406","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13406"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13406\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}