{"id":134108,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":""},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"efectos-de-la-neutropenia-inducida-por-arabinosido-de-citosina-y-de-la-inmunosupresion-farmacologica-inducida-por-metilprednisolona-y-ciclosporina-sobre-la-aspergilosis-pulmonar-invasora-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-la-neutropenia-inducida-por-arabinosido-de-citosina-y-de-la-inmunosupresion-farmacologica-inducida-por-metilprednisolona-y-ciclosporina-sobre-la-aspergilosis-pulmonar-invasora-experimental\/","title":{"rendered":"Efectos de la neutropenia inducida por arabinosido de citosina y de la inmunosupresion farmacologica inducida por metilprednisolona y ciclosporina sobre la aspergilosis pulmonar invasora experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Berenguer Berenguer <\/strong><\/h2>\n<p>La hipotesis de trabajo al comenzar nuestros experimentos ha sido que la aspergilosis pulmonar invasora se comporta de manera diferente en funcion del trastorno subyacente en los mecanismos de defensa. Para contrastar dicha hipotesis hemos desarrollado modelos experimentales de la enfermedad, centrando nuestro trabajo alrededor de los siguientes puntos: 1) comparar la evolucion natural de la aspergilosis pulmonar invasora en animales de experimentacion con distintos defectos en los mecanismos de defensa: 1a) neutropenia profunda inducida por arabinosido de citosina y 1b) inmunodepresion farmacologica inducida por metilprednisolona y\/o ciclosporina. 2) analizar los patrones de infeccion y de inflamacion tisular de la aspergilosis en los grupos arriba mencionados. 3) estudiar del papel que juegan tanto los glucocorticoides como la ciclosporina en la patogenia de la aspergilosis pulmonar invasora.  nuestros experimentos han permitido demostrar que: 1) la evolucion de la aspergilosis pulmonar invasora experimental es rapidamente mortal en presencia de neutropenia y tiene un curso mas subagudo y menos letal cuando no existe neutropenia. 2) los mecanismos de lesion tisular difieren en funcion del defecto inmunologico subyacente: en presencia de neutropenia profunda la lesion tisular es secundaria a infarto hemorragico. En ausencia de neutropenia la lesion tisular es secundaria a necrosis inflamatoria. 3) la morfolog\u00eda del hongo en tejido difiere en funcion del defecto inmunologico subyacente: en presencia de neutropenia existe abundancia de hifas plenamente desarrolladas. En ausencia de neutropenia se observa menos cantidad de hifas y mas cantidad de conidias en diferente estadio de germinacion.  4) los glucocorticoides son los principales agentes predisponentes para aspergilosis invasora. La ciclosporina tiene un papel secundario aunque puede que potencie en alguna medida la inmunosupresion inducida por los glucocorticoides.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la neutropenia inducida por arabinosido de citosina y de la inmunosupresion farmacologica inducida por metilprednisolona y ciclosporina sobre la aspergilosis pulmonar invasora experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la neutropenia inducida por arabinosido de citosina y de la inmunosupresion farmacologica inducida por metilprednisolona y ciclosporina sobre la aspergilosis pulmonar invasora experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Berenguer Berenguer <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin D\u00edaz Mediavilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Domingo Espinos Perez <\/li>\n<li>Luis Escribano Mora (vocal)<\/li>\n<li>Jos\u00e9 Luis Alvarez Sala Walther (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Eiros Bouza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Berenguer Berenguer La hipotesis de trabajo al comenzar nuestros experimentos ha sido que la aspergilosis pulmonar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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