{"id":134138,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estructura-y-dinamica-de-proteinas-por-resonancia-magnetica-nuclear-proteina-antifungica-y-alfa-sarcina\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estructura-y-dinamica-de-proteinas-por-resonancia-magnetica-nuclear-proteina-antifungica-y-alfa-sarcina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisica\/estructura-y-dinamica-de-proteinas-por-resonancia-magnetica-nuclear-proteina-antifungica-y-alfa-sarcina\/","title":{"rendered":"Estructura y dinamica de proteinas por resonancia magnetica nuclear: proteina antifungica y alfa-sarcina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ramon Campos Olivas <\/strong><\/h2>\n<p>La estructura tridimensional de la proteina antifungica de a. Giganteus (51 residuos) y de la ribonucleasa citotoxica alfa-sarcina (150 residuos) se han determinado mediante espectroscopia de resonancia magnetica nuclear multidimensional, homo- y heteronuclear. Asimismo, se ha medido el intercambio de protones amidicos y los parametros de relajacion (t1, t2 y noe) de la alfa-sarcina para caracterizar su dinamica interna. La proteina antifungica esta formada por 5 hebras beta antiparalelas que definen un barril beta altamente estabilizado por sus 4 puestes disulfuro internos. Se ha propuesto un sitio de union de fosfolipidos en la estructura que podria ser responsable de su actividad.  una forma minoritaria de esta proteina que difiere de la mayoritaria en los pares de cisteinas que forman sus 4 disulfuros: ha sido tambien caracterizada. La estructura de la alfa-sarcina es muy similar a las ribonucleasas de la familia de la t1, presentando un nucleo de plegamiento y un mecanismo catalitico analogos. Sin embargo, la alfa-sarcina presenta 3 bucles expuestos de gran tama\u00f1o que no aparecen en t1, lo que da cuenta de la elevada especificidad por su sustrato natural y de su capacidad de interaccionar con vesulas acidas. Por tanto, las estructuras determinadas han permitido por primera vez establecer relaciones estructura-funcion para estas dos proteinas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estructura y dinamica de proteinas por resonancia magnetica nuclear: proteina antifungica y alfa-sarcina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estructura y dinamica de proteinas por resonancia magnetica nuclear: proteina antifungica y alfa-sarcina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ramon Campos Olivas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Santoro Said<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Gregorio Gavilanes Franco <\/li>\n<li>Manuel Rico Sarompas (vocal)<\/li>\n<li>Juan  Jos\u00e9 Freire Gomez (vocal)<\/li>\n<li>Jes\u00fas Jim\u00e9nez-barbero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ramon Campos Olivas La estructura tridimensional de la proteina antifungica de a. Giganteus (51 residuos) y de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[986,651,199,35049,1272,560],"tags":[43719,65783,5832,1160,564,201143],"class_list":["post-134138","post","type-post","status-publish","format-standard","hentry","category-complutense-de-madrid","category-espectroscopia-molecular-en-quimica-fisica","category-fisica","category-fisica-de-macromoleculas","category-fisica-molecular","category-quimica-fisica","tag-jesus-jimenez-barbero","tag-jorge-santoro-said","tag-jose-gregorio-gavilanes-franco","tag-juan-jose-freire-gomez","tag-manuel-rico-sarompas","tag-ramon-campos-olivas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/134138","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=134138"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/134138\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=134138"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=134138"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=134138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}