{"id":13418,"date":"2018-03-09T08:59:41","date_gmt":"2018-03-09T08:59:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/acidos-grasos-en-la-progresion-del-cancer-de-mama-implicaciones-terapeuticas\/"},"modified":"2018-03-09T08:59:41","modified_gmt":"2018-03-09T08:59:41","slug":"acidos-grasos-en-la-progresion-del-cancer-de-mama-implicaciones-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/acidos-grasos-en-la-progresion-del-cancer-de-mama-implicaciones-terapeuticas\/","title":{"rendered":"Acidos grasos en la progresi\u00f3n del c\u00e1ncer de mama: implicaciones terapeuticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> JavierAbel Men\u00e9ndez Men\u00e9ndez <\/strong><\/h2>\n<p>La cantidad y el tipo de \u00e1cidos grasos ingeridos en la dieta son factores ambientales capaces de modular el riesgo de aparici\u00f3n, la presentaci\u00f3n y la subsiguiente progresi\u00f3n del c\u00e1ncer de mama. Por otro lado, las c\u00e9lulas humanas del c\u00e1ncer de mama exhiben en numerosas ocasiones niveles muy elevados de la prote\u00edna \u00e1cido graso sintasa (fas), el enzima clave en la bios\u00edntesis end\u00f3gena de \u00e1cidos grasos, adquiriendo una independecnia de las se\u00f1ales de regulaci\u00f3n habitualmente encargadas de inhibir la s\u00edntesis de \u00e1cidos grasos en las c\u00e9lulas normales. El objetivo principal de este trabajo fue determinar el papel de los \u00e1cidos grasos ex\u00f3genos (procedentes de la dieta) y end\u00f3genos (resultado de las sobre-expresi\u00f3n e hiperactividad de fas) en la progresi\u00f3n in vitro del c\u00e1ncer de mama. Los resultados obtenidos demuestran que los \u00e1cidos grasos ex\u00f3genos modulan el potencial metast\u00e1sico de las c\u00e9lulas humanas de c\u00e1ncer de mama en cultivo a tres niveles:  a,- inhibici\u00f3n (en el caso de los \u00e1cidos grasos gla,ala, epa y dha) \u00f3 estimulando (en el caso de los \u00e1cidos grasos la, ara y oa) la proliferaci\u00f3n celular.  b,- modulando la adhesividad de las c\u00e9lulas tumorales a componentes de la matriz extracelular (col\u00e1geno iv, fibronectina o matrigel).  c,- alterando la motilidad (quimiotaxis) e invasividad de las c\u00e9lulas tumorales.  por otro lado, la bios\u00edntesis end\u00f3gena de \u00e1cidos grasos catalizada por fas es un proceso metab\u00f3lico imprescindible para la superficie de las c\u00e9lulas de c\u00e1ncer de mama dado que su inhibici\u00f3n empleando el anti-metabolito cerulenina es citot\u00f3xica. La inhibici\u00f3n de la actividad enzim\u00e1tica de fas induce la acumulaci\u00f3n de las prote\u00ednas p53 y p21 waf1\/cip1, sugiriendo que la inhibici\u00f3n de la bios\u00edntesis end\u00f3gena de \u00e1cidos grasos dependiente de fas es un nuevo stress metab\u00f3lico no genot\u00f3xico regulado por la ruta de se\u00f1alizaci\u00f3n intracelular p53\/p21 waf1\/cip1.Adem\u00e1s, las c\u00e9lulas human<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acidos grasos en la progresi\u00f3n del c\u00e1ncer de mama: implicaciones terapeuticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acidos grasos en la progresi\u00f3n del c\u00e1ncer de mama: implicaciones terapeuticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 JavierAbel Men\u00e9ndez Men\u00e9ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ramon Colomer Bosch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel roman Benito de las heras <\/li>\n<li>bego\u00f1a Col\u00e1s escudero (vocal)<\/li>\n<li>Alberto Mu\u00f1oz terol (vocal)<\/li>\n<li>eduard Escrich escriche (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de JavierAbel Men\u00e9ndez Men\u00e9ndez La cantidad y el tipo de \u00e1cidos grasos ingeridos en la dieta son factores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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