{"id":134198,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/peptidos-hibridos-cecropina-a-melitina-con-accion-leishmanicida\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"peptidos-hibridos-cecropina-a-melitina-con-accion-leishmanicida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/peptidos-hibridos-cecropina-a-melitina-con-accion-leishmanicida\/","title":{"rendered":"Peptidos hibridos cecropina a-melitina con accion leishmanicida."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Diaz Achirica <\/strong><\/h2>\n<p>Se ha estudiado el mecanismo de accion de peptidos sinteticos hibridos de cecropina a y melitina con accion antibiotica sobre el protozoo parasito leishmania. Estos hibridos presentan una accion antibiotica superior a cecropina a y no son hemoliticos, como ocurre con la melitina.  el mas efectivo de los analogos testados, con una ld50 de 1 um es ca(1-8) m(1-18), formado por los 8 primeros residuos de cecropina a y los 18 primeros de melitina. El peptido actua muy rapidamente sobre promastigotes de l.Donovani, de forma dependiente de la temperatura y del potencial de membrana, pero no del ph. Provoca permeabilizacion de la membrana del parasito, con equilibrio del ph intracelular con el externo, colapso del potencial de membrana y disminucion de los niveles intracelulares de atp. La primera etapa de interaccion del peptido es electrostatica, ya que es inhibida por alta fuerza ionica y presencia de polianiones.  lipidofosfoglicano, un oligosacarido anionico presente en la membrana, protege parcialmente al parasito. La forma intracelular del parasito, el amastigote es altamente resistente a la accion del peptido, pero no cuando se encuentra en el interior del macrofago, indicando un efecto del peptido sobre esta celula, por induccion de no.  el peptido aplicado en forma topica sobre ratones infectados con l. Major provoca la remision de la ulcera, y es activo en cepas de multirresistencia a farmacos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Peptidos hibridos cecropina a-melitina con accion leishmanicida.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Peptidos hibridos cecropina a-melitina con accion leishmanicida. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Diaz Achirica <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Rivas L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Gregorio Gavilanes Franco <\/li>\n<li>David Andreu Mart\u00ednez (vocal)<\/li>\n<li>Almudena Guinea D\u00edaz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Diaz Achirica Se ha estudiado el mecanismo de accion de peptidos sinteticos hibridos de cecropina a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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