{"id":134203,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-mitocondria-de-la-celula-tubular-en-la-nefrotoxicidad-inducida-por-ciclosporina-a-efectos-del-calcio-y-adp\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"papel-de-la-mitocondria-de-la-celula-tubular-en-la-nefrotoxicidad-inducida-por-ciclosporina-a-efectos-del-calcio-y-adp","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-la-mitocondria-de-la-celula-tubular-en-la-nefrotoxicidad-inducida-por-ciclosporina-a-efectos-del-calcio-y-adp\/","title":{"rendered":"Papel de la mitocondria de la celula tubular en la nefrotoxicidad inducida por ciclosporina a. efectos del calcio y adp."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Diaz Rey Miguel Angel <\/strong><\/h2>\n<p>La ciclosporina a (csa) es un agente inmusupresor cuyo uso clinico lleva asociado la aparicion de nefrotoxicidad como efecto secundario, en la que aparecen de forma comun lesiones mitocondriales.La csa provoca la activacion de la bomba de sodio de la celula tubular aumentando el recambio de atp. Asi mismo, condiciona una disminucion en el consumo de glutamina en la celula tubular.  a nivel mitocondrial se han encontrado efectos de la ciclosporina sobre la respiracion, que es inhibida tanto en fase 3 como en fase 4, asi mismo tambien inhibe la permeabilidad inespecifica mitocondrial impidiendo la hinchazon mitocondrial que ello conlleva. En cuanto al transporte de calcio, la csa bloquea la salida de calcio dependiente de la entrada de sodio.  por todo ello, la csa favorece el acumulo de calcio en la mitocondria, siendo esta la posible explicacion de los hallazgos histologicos que se presentan en la nefrotoxicidad por csa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la mitocondria de la celula tubular en la nefrotoxicidad inducida por ciclosporina a. efectos del calcio y adp.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la mitocondria de la celula tubular en la nefrotoxicidad inducida por ciclosporina a. efectos del calcio y adp. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Diaz Rey Miguel Angel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Tejedor Jorge<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Albino Garc\u00eda Sacrist\u00e1n <\/li>\n<li>Lisardo Bosc\u00e1 Gomar (vocal)<\/li>\n<li>Mar\u00eda  Teresa Miras Portugal (vocal)<\/li>\n<li>Juan  Emilio Feliu Albi\u00f1ana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diaz Rey Miguel Angel La ciclosporina a (csa) es un agente inmusupresor cuyo uso clinico lleva asociado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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