{"id":134388,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-manifestaciones-tempranas-en-los-procesos-neurodegenerativos-de-tipo-hipoxia-isquemia\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-de-las-manifestaciones-tempranas-en-los-procesos-neurodegenerativos-de-tipo-hipoxia-isquemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-las-manifestaciones-tempranas-en-los-procesos-neurodegenerativos-de-tipo-hipoxia-isquemia\/","title":{"rendered":"Estudio de las manifestaciones tempranas en los procesos neurodegenerativos de tipo hipoxia-isquemia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlota Largo Aramburu <\/strong><\/h2>\n<p>El objetivo de este trabajo fue estudiar las consecuencias del fallo energetico glial en la funcion neuronal y el mecanismo de propagacion de las ondas de leao (dl), factores criticos involucrados en la muerte neuronal isquemica. 1. El envenenamiento metabolico selectivo de las celulas gliales in situ, causa la perdida de la homeostasis extracelular, e inicia un deterioro progresivo de la funcion neuronal, causado por la aparicion espontanea de ondas dl que finaliza con la muerte de estas celulas.  2. Las ondas dl solo son da\u00f1inas para las neuronas cuando la funcion glial esta disminuida o impedida.  3. Las uniones electronicas entre neuronas son necesarias para la propagacion de la onda dl por tejido nervioso.  4. El mecanismo generador del potencial extracelular registrado durante la dl, obedece a corrientes espaciales a lo largo del eje de las celulas piramidales, originadas por el desarrollo de un gradiente de despolarizacion longitudinal.  estos resultados ponen de manifiesto la importancia de una disfuncion glial temprana en la muerte neuronal en la zona de penumbra isquemica y abren nuevas posibilidades terapeuticas basadas en la preservacion de la funcion de estas celulas y la detencion de las ondas de leao.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las manifestaciones tempranas en los procesos neurodegenerativos de tipo hipoxia-isquemia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las manifestaciones tempranas en los procesos neurodegenerativos de tipo hipoxia-isquemia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlota Largo Aramburu <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00f3scar Herreras Espinosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Mora Teruel <\/li>\n<li>Fernando Carceller Benito (vocal)<\/li>\n<li>Juan Lerma Gomez (vocal)<\/li>\n<li>Juan  Vicente Sanchez Andres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlota Largo Aramburu El objetivo de este trabajo fue estudiar las consecuencias del fallo energetico glial en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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