{"id":13452,"date":"2018-03-09T08:59:44","date_gmt":"2018-03-09T08:59:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-casos-y-controles-sobre-factores-de-riesgo-y-suceptibilidad-genetica-en-el-cancer-de-pulmon\/"},"modified":"2018-03-09T08:59:44","modified_gmt":"2018-03-09T08:59:44","slug":"estudio-de-casos-y-controles-sobre-factores-de-riesgo-y-suceptibilidad-genetica-en-el-cancer-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-casos-y-controles-sobre-factores-de-riesgo-y-suceptibilidad-genetica-en-el-cancer-de-pulmon\/","title":{"rendered":"Estudio de casos y controles sobre factores de riesgo y suceptibilidad gen\u00e9tica en el c\u00e1ncer de pulm\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Ruano Ravi\u00f1a <\/strong><\/h2>\n<p>Introducci\u00f3n  el c\u00e1ncer de pulm\u00f3n es un importante problema sanitario en la actualidad. es la primera causa de muerte por c\u00e1ncer en hombres y en las mujeres ya ha superado al c\u00e1ncer de mama en algunos pa\u00edses desarrollados.Si bien en galicia la incidencia de este c\u00e1ncer es a\u00fan baja en mujeres, se espera un gran aumento debido a todas aquellas que comenzaron a fumar en las \u00faltimas d\u00e9cadas.  objetivos  1,- determinar el riesgo de c\u00e1ncer de pulm\u00f3n asociado a diversos factores ambientales como tabaco, ocupaci\u00f3n, dieta y exposici\u00f3n a sustancias qu\u00edmicas.  2,- determinar si existe riesgo de c\u00e1ncer de pulm\u00f3n relacionado con la presencia o la ausencia de los genes gstm1 y gstt1.  3,- determinar si existe modificaci\u00f3n de efecto entre ambos genes y las exposiciones ambientales.  sujetos y m\u00e9todos  estudio de casos y controles de base hospitalaria en el \u00e1rea sanitaria de santiago de compostela realizado entre 1999 y 2000 con un muestreo por frecuencia de sexo. Los casos fueron 132 sujetos diagnosticados anatomopatol\u00f3gicamente de c\u00e1ncer de pulm\u00f3n. Los controles fueron 187 individuos sometidos a cirug\u00eda banal. Se exluyeron sujetos menores de 30 a\u00f1os, con antecedentes neopl\u00e1sicos, casos prevalentes y sujetos sometidos a cirug\u00eda mayor. A todos los indiviudos se les realiz\u00f3 una entrevista personal en la que se les pregunt\u00f3 por diversos aspectos de su estilo de vida (tabaco, ocupaci\u00f3n,  dieta &#8230;) Y les fueron extraidos 6ml de sangre total previo consentimiento informado (procedimiento aprobado por el comit\u00e9 \u00e9tico de investigaciones cl\u00ednicas de galicia). En la fracci\u00f3n de gl\u00f3bulos blancos se  determin\u00f3 mediante pcr la presencia o ausencia de los genes gstm1 y gstt1. para el an\u00e1lisis estad\u00edstico se realiz\u00f3 una regresi\u00f3n log\u00edstica y para el an\u00e1lisis de ciertas variables del tabaco se utilizaron regresiones log\u00edsticas con modelos aditivos generalizados gam. Se realiz\u00f3 un modelo final con todas aquellas var<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de casos y controles sobre factores de riesgo y suceptibilidad gen\u00e9tica en el c\u00e1ncer de pulm\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de casos y controles sobre factores de riesgo y suceptibilidad gen\u00e9tica en el c\u00e1ncer de pulm\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Ruano Ravi\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Miguel Barros Dios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jes\u00fas Gestal otero <\/li>\n<li>n\u00faria Malats riera (vocal)<\/li>\n<li>agustin Montes Martinez (vocal)<\/li>\n<li>Fernando Rodr\u00edguez artalejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Ruano Ravi\u00f1a Introducci\u00f3n el c\u00e1ncer de pulm\u00f3n es un importante problema sanitario en la actualidad. es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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