{"id":134527,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-cd44s-y-sus-isoformas-variantes-v5-y-v6-en-carcinomas-pulmonares-no-microciticos-correlacion-con-otros-parametros-clinico-biologicos\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"expresion-del-cd44s-y-sus-isoformas-variantes-v5-y-v6-en-carcinomas-pulmonares-no-microciticos-correlacion-con-otros-parametros-clinico-biologicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/expresion-del-cd44s-y-sus-isoformas-variantes-v5-y-v6-en-carcinomas-pulmonares-no-microciticos-correlacion-con-otros-parametros-clinico-biologicos\/","title":{"rendered":"Expresion del cd44s y sus isoformas variantes v5 y v6 en carcinomas pulmonares no microciticos. correlacion con otros parametros clinico-biologicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Nu\u00f1ez Villar Matilde Isabel <\/strong><\/h2>\n<p>Con objeto de estudiar su comportamiento, asi como su posible utilidad como factores pronosticos, hemos determinado las concentraciones de cd44s, cd44v5 y cd44v6 en 208 tejidos pulmonares (95 carcinomas escamosos, 59 adenocarcinomas y 54 tejidos normales procedente de pacientes con ambos tipos de carcinomas. Tanto el tejido tu moral como el no neoplasico expresaron las tres moleculas de adhesion. En los carcinomas escamosos, la expresion del cd44s y las isoformas variantes se asociaron con altas concentraciones de parametros biologicos de mal pronostico. Los adenocarcinomas sin expresion de cd44s ni cd44v5 presentaron altas concentraciones de acido hialuronico de membrana (ahm), ligando del cd44, y la ausencia de la expresion de cd44s se asocio con un menor tiempo libre de enfermedad. El analisis multivariante demostro que solo el estadio y el ahm(dintel de positividad: 855 ng\/mg prt.) Fueron factores pronosticos independientes para el tiempo libre de enfermedad. Dentro de cada estadio clinico, la positividad para el ahm determino un riesgo relativo 4 veces superior a cuando el proteoglicano fue negativo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion del cd44s y sus isoformas variantes v5 y v6 en carcinomas pulmonares no microciticos. correlacion con otros parametros clinico-biologicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion del cd44s y sus isoformas variantes v5 y v6 en carcinomas pulmonares no microciticos. correlacion con otros parametros clinico-biologicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Nu\u00f1ez Villar Matilde Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alvaro Ruibal Morell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Balibrea  Cantero <\/li>\n<li>Fernando Vidal Vanoclocha (vocal)<\/li>\n<li>Santiago Rodr\u00edguez-segade Villamar\u00edn (vocal)<\/li>\n<li>Crist\u00f3bal Mezquita Pl\u00e1 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nu\u00f1ez Villar Matilde Isabel Con objeto de estudiar su comportamiento, asi como su posible utilidad como factores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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