{"id":13460,"date":"2018-03-09T08:59:45","date_gmt":"2018-03-09T08:59:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-y-disposicion-tisular-de-azitromicina-en-el-conejo\/"},"modified":"2018-03-09T08:59:45","modified_gmt":"2018-03-09T08:59:45","slug":"farmacocinetica-y-disposicion-tisular-de-azitromicina-en-el-conejo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-y-disposicion-tisular-de-azitromicina-en-el-conejo\/","title":{"rendered":"Farmacocin\u00e9tica y disposici\u00f3n tisular de azitromicina en el conejo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Dolores Najera Perez <\/strong><\/h2>\n<p>Se ha estudiado el comportamiento cin\u00e9tico de la azitromicina administrada por v\u00eda intravenosa e intramuscular en conjeo, tras una dosis \u00fanica de 10 mg\/kg, as\u00ed mismo se ha estudiado la farmacocin\u00e9tica tisular de la misma dosis de f\u00e1rmaco, tras las citadas v\u00edas de administraci\u00f3n. El objetivo ha sido establecer los par\u00e1metros farmacocin\u00e9ticos del f\u00e1rmaco por las v\u00edas de administraci\u00f3n estudiadas, as\u00ed como estudiar la distribuci\u00f3n de azitromicina en tejidos seleccionados de conejos. As\u00ed mismo se han estudiado las pautas posol\u00f3gicas m\u00e1s adecuadas de este antibi\u00f3tico en el conejo.  la determinaci\u00f3n de la azitromicina tanto en plasma como en los distintos tejidos, se ha realizado siguiendo la t\u00e9cnica de bioensayo, descrita previamente por girard y cols., (1987): el ajuste farmacocin\u00e9ticos se realiz\u00f3 con los programas pkcalc (shumaker, 1986) y multi (yamaoka y cols., 1986), consider\u00e1ndose el criterio de informaci\u00f3n de akaike (aic) el par\u00e1mero determinante para elegir el modelo farmacocin\u00e9tico m\u00e1s adecuado (yamaoka y cols., 1978).  la azitromicina tras su administraci\u00f3n intravenosa se ajusta a un modelo tricompartimental abierto, mientras que tras su administraci\u00f3n intramuscular se ajusta a un modelo bicompartimental abierto.  el comportamiento farmacocin\u00e9tico de la azitromicina, en nuestro estudio, se caracteriza por la presencia de unas concentraciones plasm\u00e1ticas bajas y  sostenidas, y por el contrario unas concentraciones, en los distintos tejidos estudiados, elevadas y persistentes. El an\u00e1lisis de los distintos par\u00e1metros cin\u00e9ticos obtendios tras la administraci\u00f3n intravenosa nos indican la elevada retenci\u00f3n que sufre el f\u00e1rmaco en los compartimentos perif\u00e9ricos.  las concentraciones tisulares m\u00e1s elevadas se han encontrado en bilis e h\u00edgado, por el contrario las m\u00e1s bajas se han econtrado en el tejido muscular, aunque de cualquier modo son muy superiores a las plasm\u00e1ticas.  por \u00faltimo, las al<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica y disposici\u00f3n tisular de azitromicina en el conejo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica y disposici\u00f3n tisular de azitromicina en el conejo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Dolores Najera Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Mario Carceles Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Brugger auban arturo jose <\/li>\n<li>Antonio Contreras de vera (vocal)<\/li>\n<li> Del rio Garc\u00eda Jes\u00fas (vocal)<\/li>\n<li> San Miguel zamora Mar\u00eda aoria teresa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Dolores Najera Perez Se ha estudiado el comportamiento cin\u00e9tico de la azitromicina administrada por v\u00eda intravenosa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,9,515,2445,957,6530,5675,9740,8235],"tags":[43701,43700,24978,43702,43699,43703],"class_list":["post-13460","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-medicas","category-ciencias-veterinarias","category-evaluacion-de-farmacos","category-farmacologia","category-farmacologia-experimental","category-farmacologia-veterinaria","category-farmacos-sinteticos","category-murcia","tag-antonio-contreras-de-vera","tag-brugger-auban-arturo-jose","tag-carlos-mario-carceles-rodriguez","tag-del-rio-garcia-jesus","tag-m-dolores-najera-perez","tag-san-miguel-zamora-maria-aoria-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13460","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13460"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13460\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13460"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13460"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13460"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}