{"id":134698,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-citotoxicidad-del-factor-de-necrosis-tumoral-alfa-en-las-lineas-celulares-l929-y-hepg2\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"mecanismos-de-citotoxicidad-del-factor-de-necrosis-tumoral-alfa-en-las-lineas-celulares-l929-y-hepg2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-de-citotoxicidad-del-factor-de-necrosis-tumoral-alfa-en-las-lineas-celulares-l929-y-hepg2\/","title":{"rendered":"Mecanismos de citotoxicidad del factor de necrosis tumoral-alfa en las lineas celulares l929 y hepg2."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sanchez Pobre Bejarano Pilar <\/strong><\/h2>\n<p>En la presente tesis hemos analizado los mecanismos de citotoxicidad inducidos por el tnf sobre las lineas celulares l929 y hepg2. Para ello hemos estudiado los efectos inducidos por el tnf, en presencia o ausencia de inhibidores metabolicos, sobre la citotoxicidad, la carga energetica, los niveles de atp, el grado de acoplamiento respiratorio mitocondrial, la produccion de radicales libres de oxigeno y las alteraciones mitocondriales ultraestructurales. Asi mismo, hemos establecido la relacion entre estos efectos y la muerte celular inducida por el tnf en presencia de inhibidores metabolicos.  la conclusion de estos estudios es que el tnf, en celulas inhibidas metabolicamente con actinomicina d o cicloheximida, provoca un acoplamiento de la respiracion mitocondrial que conduce a un aumento del atp mitocondrial. Este aumento bloquearia el paso de electrones a traves del citocromo b y determinaria su desvio hacia la formacion de radicales libres de oxigeno.  sugerimos que estos radicales son los responsables de las lesiones mitocondriales y en ultimo extremo de la muerte celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de citotoxicidad del factor de necrosis tumoral-alfa en las lineas celulares l929 y hepg2.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de citotoxicidad del factor de necrosis tumoral-alfa en las lineas celulares l929 y hepg2. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sanchez Pobre Bejarano Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Solis  Herruzo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Enr\u00edquez De Salamanca Lorente <\/li>\n<li>Ricardo Moreno Otero (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Ladero Quesada (vocal)<\/li>\n<li>Agust\u00edn Albillos Mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sanchez Pobre Bejarano Pilar En la presente tesis hemos analizado los mecanismos de citotoxicidad inducidos por el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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