{"id":134759,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-de-la-indometacina-en-ovidos\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"farmacocinetica-de-la-indometacina-en-ovidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/farmacocinetica-de-la-indometacina-en-ovidos\/","title":{"rendered":"Farmacocinetica de la indometacina en ovidos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Emma Vinagre Diaz <\/strong><\/h2>\n<p>Se ha realizado un estudio del comportamiento farmacocinetico de la indometacina tras su administracion endovenosa, intramuscular e intrarruminal a ovejas adultas. Se ha dise\u00f1ado un cuadrado latino con 7 animales en los que se determino la concentracion plasmatica del farmaco mediante clae. Tras su administracion endovenosa (1 mg\/kg), los resultados de las concentraciones plasmaticas se ajustan a un modelo bicompartimental abierto con eliminacion de primer orden. La indometacina se distribuye con rapidez y facilidad por todos los tejidos. Las concentraciones plasmaticas de este farmaco despues de su administracion intramuscular (1 mg\/kg) tambien se ajustan a un modelo bicompartimental con absorcion y eliminacion de primer orden; la absorcion se produce rapidamente y la extension de la fase de distribucion es semejante a la obtenida tras la administracion endovenosa (vd=4,96 1\/kg). La eliminacion es mas lenta (beta=0,05 h-1), pudiendo justificar estas diferencias con respecto a la i.V. Por las variaciones en el metabolismo de los farmacos segun la via de administracion y la posible participacion del circuito enterohepatico en la cinetica del farmaco. Los datos conseguidos tras la administracion intrarruminal se ajustan a un modelo no compartimental y presentan elevadas variaciones interindividuales por la influencia de la fisiolog\u00eda digestiva de los rumiantes. Las concentraciones plasmaticas se mantienen durante 24-72 h postadministracion en la mayoria de las ovejas, apareciendo varios picos de concentracion a diferentes tmax.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocinetica de la indometacina en ovidos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocinetica de la indometacina en ovidos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Emma Vinagre Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> San Andr\u00e9s Larrea M. Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Emilio Ballesteros Moreno <\/li>\n<li>Miguel Angel Bregante Ucedo (vocal)<\/li>\n<li>\u00e1ngel Villar Del Fresno (vocal)<\/li>\n<li>Carlos Boggio Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Emma Vinagre Diaz Se ha realizado un estudio del comportamiento farmacocinetico de la indometacina tras su administracion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,515,986,5675,1944,1946],"tags":[4663,5071,5677,248908,5679,153144],"class_list":["post-134759","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-veterinarias","category-complutense-de-madrid","category-farmacologia-veterinaria","category-ovinos","category-produccion-animal","tag-angel-villar-del-fresno","tag-carlos-boggio-juan","tag-emilio-ballesteros-moreno","tag-emma-vinagre-diaz","tag-miguel-angel-bregante-ucedo","tag-san-andres-larrea-m-dolores"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/134759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=134759"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/134759\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=134759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=134759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=134759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}