{"id":13482,"date":"2018-03-09T08:59:47","date_gmt":"2018-03-09T08:59:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-prospectivo-biomoleculares-de-las-mutaciones-de-los-genes-p53-y-k-ras-en-pacientes-sometidas-a-tratamientos-con-tamoxifeno\/"},"modified":"2018-03-09T08:59:47","modified_gmt":"2018-03-09T08:59:47","slug":"estudio-prospectivo-biomoleculares-de-las-mutaciones-de-los-genes-p53-y-k-ras-en-pacientes-sometidas-a-tratamientos-con-tamoxifeno","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-prospectivo-biomoleculares-de-las-mutaciones-de-los-genes-p53-y-k-ras-en-pacientes-sometidas-a-tratamientos-con-tamoxifeno\/","title":{"rendered":"Estudio prospectivo biomoleculares de las mutaciones de los genes p53 y k-ras en pacientes sometidas a tratamientos con tamoxifeno"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marina Higueras Villaverde <\/strong><\/h2>\n<p>El tamoxifeno es el agente antineopl\u00e1stico m\u00e1s ampliamente prescrito hoy d\u00eda en todo el mundo en el tratamiento del c\u00e1ncer de mama. Es terapia de elecci\u00f3n en este tipo de c\u00e1ncer considerado el m\u00e1s frecuente en los pa\u00edses occidentales.  numerosos trabajos han relacionado el f\u00e1rmaco con la aparici\u00f3n de patolog\u00eda endometrial t\u00edpicamente estr\u00f3geno dependiente. En nuestro estudio analizamos por la t\u00e9cnica de pcr-sscp las mutaciones de los genes p53 y k-ras en 37 biopsias correspondientes a distintas patolog\u00edas endometriales de mujeres tratadas con tamoxifeno por c\u00e1ncer de mama por espacio m\u00ednimo de un a\u00f1o.  para ello, optimizamos tanto la extracci\u00f3n de adn a partir de tejido fijado con formol e incluido en parafina,a s\u00ed como las condiciones de la reacci\u00f3n de pcr y de la t\u00e9cnica de polimorfismo de conformaci\u00f3n en hebra simple de adn (sscp). No encontramos mutaci\u00f3n del gen k-ras en ninguna de las muestras analizadas. S\u00f3lo una muestra que correspond\u00eda con una paciente que hab\u00eda desarrollado un carcinosarcoma mutaci\u00f3n de ex\u00f3n 7 del pen p53.  en este estudio concluimos que el tamoxifeno se puede considerar posiblemente un f\u00e1rmaco promotor de tumores por su acci\u00f3n estrog\u00e9nica sobre el endometrio pero siempre seg\u00fan la dosis y el tiempo de tratamiento administrado.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio prospectivo biomoleculares de las mutaciones de los genes p53 y k-ras en pacientes sometidas a tratamientos con tamoxifeno<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio prospectivo biomoleculares de las mutaciones de los genes p53 y k-ras en pacientes sometidas a tratamientos con tamoxifeno <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marina Higueras Villaverde <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Nogales Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Aneiros cachaza <\/li>\n<li>isicio Ortega medina (vocal)<\/li>\n<li>Francisco Revelles mar\u00edn (vocal)<\/li>\n<li>guillermo S\u00e1nchez salgado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marina Higueras Villaverde El tamoxifeno es el agente antineopl\u00e1stico m\u00e1s ampliamente prescrito hoy d\u00eda en todo el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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