{"id":134873,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-de-silimarina-y-silibinina-sobre-el-estatus-oxidativo-tisular\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-del-efecto-de-silimarina-y-silibinina-sobre-el-estatus-oxidativo-tisular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-de-silimarina-y-silibinina-sobre-el-estatus-oxidativo-tisular\/","title":{"rendered":"Estudio del efecto de silimarina y silibinina sobre el estatus oxidativo tisular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Ure\u00f1a Garnica <\/strong><\/h2>\n<p>Se ha estudiado el efecto de silimarina z, silibinina b ciclodextrina y silibinina hemisuccinato sobre los distintos componentes bioquimicos del estatus oxidativo tisular, es decir, peroxidacion lipidica y sistema antioxidante del glutation.Para valorar si las diferencias encontradas entre los compuestos se deben a un componente farmacocinetico o farmacodinamico, se han realizado dos tipos de experiencias, in vitro y ex vivo.  los tres compuestos estudiados presentan un efecto antiperoxidativo lipidico en tejido hepatico, renal y cerebral de rata, de forma concentracion dependiente. No se observan diferencias entre los tres farmacos con respecto a la actividad enzimatica glutation peroxidasa tisular, pero si en lo que respecta a la actividad glutation reductasa y glutation transferasa, siendo la silimarina z la que presento un mayor efecto proporcional. Los experimentos ex vivos muestran un mayor efecto en la inhibicion de la peroxidacion lipidica que sobre el sistema de glutation. La silibinina hemisuccinato al administrarla oralmente muestra mayor efecto antioxidante que in vitro. Por lo que no puede descartarse una bioactivacion del compuesto.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto de silimarina y silibinina sobre el estatus oxidativo tisular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto de silimarina y silibinina sobre el estatus oxidativo tisular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Ure\u00f1a Garnica <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Pedro De La Cruz Cort\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Lafuente <\/li>\n<li>Juan  Manuel Ignacio Garcia (vocal)<\/li>\n<li>Raul Jes\u00fas Andrade Bellido (vocal)<\/li>\n<li>Francisco Martos Crespo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Ure\u00f1a Garnica Se ha estudiado el efecto de silimarina z, silibinina b ciclodextrina y silibinina hemisuccinato [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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