{"id":13495,"date":"2018-03-09T08:59:48","date_gmt":"2018-03-09T08:59:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-papel-del-acido-retinoico-en-la-morfogenesis-de-los-dedos\/"},"modified":"2018-03-09T08:59:48","modified_gmt":"2018-03-09T08:59:48","slug":"estudio-del-papel-del-acido-retinoico-en-la-morfogenesis-de-los-dedos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-del-papel-del-acido-retinoico-en-la-morfogenesis-de-los-dedos\/","title":{"rendered":"Estudio del papel del acido retinoico en la morfogenesis de los dedos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Santesteban Otazu <\/strong><\/h2>\n<p>La presente tesis analiza el papel del acido retinoico en la morfogenesis de los dedos. Para ello, se cuantifico y determino los distintos retinoides presentes en el autopodio durante la etapa de formacion de los dedos, se analizo el patron de expresion de genes involucrados en el metabolismo de la vitamina a como son raldh-2 y cyp26, el de los genes que califican para los receptores rarb y rarg y el de la proteina citoplasmatica de union a acido retinoico crabp-1 y se valoro el papel del acido retinoico en la muerte interdigital, en la condrogenesis y en la diferenciacion del tendon.  las conclusiones obtenidas fueron las siguientes:  1\u00aa)-los retinoides estan presentes en cantidades significativas durante el desarrollo de los dedos.  2\u00aa)-los datos sobre cuantificacion y los referentes a la expresion de los distintos genes analizados nos indican que el acido retinoico se sintetiza inicialmente en mayor proporcion en la region interdigital y posteriormente en los radios digitales.  3\u00aa)-el acido retinoico inducela muerte celular a traves de bmps.  4\u00aa)-el acido retinoico inhibe la condrogenesis.  5\u00aa)-el acido retinoico inhibe la diferenciacion del tendon regulando la expresion de genes involugrados en la diferenciacion del tejido conectivo como nov.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del papel del acido retinoico en la morfogenesis de los dedos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del papel del acido retinoico en la morfogenesis de los dedos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Santesteban Otazu <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Mario Hurle Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garcia-porrero perez Juan  Antonio <\/li>\n<li>Jos\u00e9 Carlos Rodriguez rey (vocal)<\/li>\n<li>Jes\u00fas Chimal monroy (vocal)<\/li>\n<li>Mar\u00eda  angeles Ros lasierra (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Santesteban Otazu La presente tesis analiza el papel del acido retinoico en la morfogenesis de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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