{"id":13510,"date":"2018-03-09T08:59:49","date_gmt":"2018-03-09T08:59:49","guid":{"rendered":""},"modified":"2018-03-09T08:59:49","modified_gmt":"2018-03-09T08:59:49","slug":"actividad-de-los-promotores-en-sentido-del-virion-de-los-geminivirus-msv-y-wdv-papel-de-las-protea%c2%adnas-no-estructurales-e-interaccion-con-rutas-celulares-de-regulacion-de-la-expresion-genica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/actividad-de-los-promotores-en-sentido-del-virion-de-los-geminivirus-msv-y-wdv-papel-de-las-protea%c2%adnas-no-estructurales-e-interaccion-con-rutas-celulares-de-regulacion-de-la-expresion-genica\/","title":{"rendered":"Actividad de los promotores en sentido del viri\u00f3n de los geminivirus msv y wdv. papel de las prote\u00ednas no estructurales e interacci\u00f3n con rutas celulares de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mu\u00f1oz Mart\u00edn M. \u00e1ngeles <\/strong><\/h2>\n<p>Los geminivirus msv (virus del estriado del ma\u00edz) y wdv (virus del enanismo del trigo), pertenecientes al g\u00e9nero mastrevirus, son unos virus vegetales que infectan monocotiled\u00f3neas cuyo material gen\u00e9tico consiste en una mol\u00e9cula de dna de cadena sencilla circular de aproximadamente 2.7 kb. Replican y transcriben su genoma v\u00eda un intermediario de cadena doble. La transcripci\u00f3n ocurre de manera bidireccional a partir de una regi\u00f3n interg\u00e9nica que no codifica ninguna prote\u00edna, produciendo solo 4 prote\u00ednas. Hacia la derecha o en sentido del viri\u00f3n (o v) las prote\u00ednas de movimiento y de la c\u00e1pside (v1 y v2 respectivamente), y hacia la izquierda, o en el sentido complementario las prote\u00ednas no estructurales c1 o repa y c1c2 o rep, ambas por procesamiento diferencial del mismo tr\u00e1nscrito. Al codificar tan pocas prote\u00ednas necesitan de la maquinaria celular tanto para replicar como para transcribir su genoma, en combinaci\u00f3n con las prote\u00ednas no estructurales. La prote\u00edna rep es necesaria para el inicio de la replicaci\u00f3n por el mecanismo del circulo rodante, mientras que repa de wdv parece estar implicada en la activaci\u00f3n de la transcripci\u00f3n en sentido del viri\u00f3n, aunque durante mucho tiempo se asign\u00f3 este papel a rep y no esta claro si \u00e9sta tambi\u00e9n contribuye en la funci\u00f3n activadora. Ambas prote\u00ednas son modulares pudiendo ejercer varias funciones y se ha comprobado que tanto rep como repa de wdv y repa de msv interaccionan, mediante un motivo conservado, con la prote\u00edna celular de reinoblastoma (rb), prote\u00edna clave en la progresi\u00f3n de ciclo celular de fase g1 a s en mam\u00edferos mediante la interacci\u00f3n con el factor transcripcional e2f, pudiendo interferir con la regulaci\u00f3n del ciclo celular de plantas.  nosotros nos hemos interesado en el estudio de la transcripci\u00f3n en sentido v de estos dos virus, mediante experimentos de expresi\u00f3n transitoria en hojas de ma\u00edz y estable en plantas de tabaco y en el papel que las<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad de los promotores en sentido del viri\u00f3n de los geminivirus msv y wdv. papel de las prote\u00ednas no estructurales e interacci\u00f3n con rutas celulares de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad de los promotores en sentido del viri\u00f3n de los geminivirus msv y wdv. papel de las prote\u00ednas no estructurales e interacci\u00f3n con rutas celulares de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mu\u00f1oz Mart\u00edn M. \u00e1ngeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Fenoll Comes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Almendral del rio <\/li>\n<li>sylvie Collin (vocal)<\/li>\n<li>eduardo Rodr\u00edguez bejarano (vocal)<\/li>\n<li>isabel D\u00edaz rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mu\u00f1oz Mart\u00edn M. \u00e1ngeles Los geminivirus msv (virus del estriado del ma\u00edz) y wdv (virus del enanismo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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