{"id":135151,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-dexametasona-sobre-la-respuesta-relajante-muscular-inducida-por-agonistas-beta-adrenergicos-en-traquea-de-cobayo\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"efectos-de-la-dexametasona-sobre-la-respuesta-relajante-muscular-inducida-por-agonistas-beta-adrenergicos-en-traquea-de-cobayo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/efectos-de-la-dexametasona-sobre-la-respuesta-relajante-muscular-inducida-por-agonistas-beta-adrenergicos-en-traquea-de-cobayo\/","title":{"rendered":"Efectos de la dexametasona sobre la respuesta relajante muscular inducida por agonistas beta-adrenergicos en traquea de cobayo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Seco Garcia Ana Jose <\/strong><\/h2>\n<p>La asociacion de agonistasbeta-adrenergicos y glucocorticoides en el tratamiento del asma bronquial puede provocar interacciones. El objetivo de esta tesis fue estudiar el efecto de la administracion \u00abin vivo\u00bb de agonistas beta y su modificacion por la asociacion de glucocorticoides. Utilizamos cobayos que dividimos en tres grupos experimentales: 1) no tratados, 2) tratados con salbutamol (0,8 mg\/kg\/dia), solo o combinado con dexametasona (0,2 mg\/kg\/dia), durante 7 dias, y 3) tratados con terbutalina (100 mg\/kg\/dia), sola o combinada con dexametasona (0,2 y 2 mg\/kg\/dia), 7 dias.  posteriormente, se sacrificaron los cobayos y se estudio la respuesta \u00abin vitro\u00bb de la traquea de cobayo. Los agonistas beta relajaron de forma concentracion-dependiente la contraccion inducida por carbacol (3 mu m), siendo el orden de potencia y eficacia:  fenoterol  mayor que  salbutamol  mayor o igual que terbutalina. La indometacina \u00abin vitro\u00bb, pero no la dexametasona, abolio el tono basal de la preparacion e incremento la respuesta frente al carbacol y a los agonistas beta. El tratamiento con una dosis baja de salbutamol, solo o combinado con dexametasona no modifico la relajacion \u00abin vitro\u00bb a los agonistas beta. Sin embargo, el tratamiento con una dosis alta de terbutalina redujo significativamente dicha relajacion (p&lt;0,01), sin cambiar la contraccion inducida por el carbacol, y la asociacion de dexametasona no tuvo efecto sobre esa reduccion. En conclusion, dosis bajas de agonistas beta -adrenergicos no modifican la respuestabeta-adrenergica de la traquea de cobayo, pero dosis altas inducen una desensibilizacion \u00abin vivo\u00bb. La asociacion de dexametasona a este tratamiento no modifica la desensibilizacion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la dexametasona sobre la respuesta relajante muscular inducida por agonistas beta-adrenergicos en traquea de cobayo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la dexametasona sobre la respuesta relajante muscular inducida por agonistas beta-adrenergicos en traquea de cobayo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Seco Garcia Ana Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gloria Manso Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Agustin Hidalgo Balsera <\/li>\n<li>Mar\u00eda  Isabel Martin Fontelles (vocal)<\/li>\n<li> De Andr\u00e9s Rodriguez-trelles Fernando (vocal)<\/li>\n<li>Luis Molinos Martin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Seco Garcia Ana Jose La asociacion de agonistasbeta-adrenergicos y glucocorticoides en el tratamiento del asma bronquial puede [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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