{"id":135273,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-resistencia-a-drogas-y-enfermedad-minima-residual-en-leucemias-mieloblasticas-agudas-mediante-citometria-de-flujo-relacion-con-el-pronostico-de-la-enfermedad\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"determinacion-de-resistencia-a-drogas-y-enfermedad-minima-residual-en-leucemias-mieloblasticas-agudas-mediante-citometria-de-flujo-relacion-con-el-pronostico-de-la-enfermedad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/determinacion-de-resistencia-a-drogas-y-enfermedad-minima-residual-en-leucemias-mieloblasticas-agudas-mediante-citometria-de-flujo-relacion-con-el-pronostico-de-la-enfermedad\/","title":{"rendered":"Determinacion de resistencia a drogas y enfermedad minima residual en leucemias mieloblasticas agudas mediante citometria de flujo: relacion con el pronostico de la enfermedad."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Agustin Martinez Escribano <\/strong><\/h2>\n<p>Se analiza el valor del inmunofenotipo en la deteccion de enfermedad minima residual en pacientes con leucemia mieloblastica aguda. Igualmente se explora, mediante tecnica funcional, la expresion de la proteina relacionada con el gen de resistencia a multiples drogas (mdr-1) en los blastos mieloides y su relacion con la aparicion de resistencia a la quimioterapia. El numero absoluto de blastos cuantificados mediante inmunofenotipo en el momento de la remision completa (rc) morfologica tras quimioterapia de induccion\/intensificacion identifico pacientes con pronostico significativamente diferente. Asi, mientras los criterios morfologicos-citoquimicos clasicos fueron incapaces de separar grupos de pacientes con supervivencias distintas, el detectar mediante estudio inmunofenotipico un numero absoluto de celulas blasticas mayor o igual que 5 por 10 elevado a 3 o mayor o igual que 2 por 10 elevado a 3 tras el tratamiento de induccion o intensificacion, respectivamente, se asocio con una supervivencia global y libre de enfermedad significativamente peor que los pacientes con un numero inferior de blastos.  la relacion con el nivel de resistencia a drogas cuantificada mediante ensayo funcional de la proteina mdr-1, se observo una asociacion entre el nivel de resistencia a drogas y alcanzar remision completa y con la duracion de la supervivencia libre de enfermedad.  igualmente, el numero de blastos en la medula osea en rc tras tratamiento de induccion y\/o intensificacion se relaciono con el nivel de resistencia a drogas, determinado mediante la prueba funcional de eliminacion de rodamina 123, en los blastos leucemicos en el momento del diagnostico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinacion de resistencia a drogas y enfermedad minima residual en leucemias mieloblasticas agudas mediante citometria de flujo: relacion con el pronostico de la enfermedad.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinacion de resistencia a drogas y enfermedad minima residual en leucemias mieloblasticas agudas mediante citometria de flujo: relacion con el pronostico de la enfermedad. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Agustin Martinez Escribano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Fernando San Miguel Izquierdo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Javier Alvarez Guisasola <\/li>\n<li>Jos\u00e9 Mar\u00eda Moraleda Jim\u00e9nez (vocal)<\/li>\n<li>Agustin Rios Gonzalez (vocal)<\/li>\n<li>Luis Escribano Moral (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Agustin Martinez Escribano Se analiza el valor del inmunofenotipo en la deteccion de enfermedad minima residual en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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