{"id":135294,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-y-evaluacion-de-heterocombretastatinas-heterolignanolidas-y-compuestos-relacionados\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"sintesis-y-evaluacion-de-heterocombretastatinas-heterolignanolidas-y-compuestos-relacionados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-y-evaluacion-de-heterocombretastatinas-heterolignanolidas-y-compuestos-relacionados\/","title":{"rendered":"Sintesis y evaluacion de heterocombretastatinas, heterolignanolidas y compuestos relacionados."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angel Custodio Ramos Sanchez <\/strong><\/h2>\n<p>En este trabajo se ha realizado la sintesis y determinacion estructural de  heterocombretastatinas y heterolignanolidas, analogos de combretastatinas y lignanolidas en los que se ha sustituido un anillo aromatico por otro heteroaromatico. Para su obtencion se ha puesto a punto una metodolog\u00eda sintetica basada en la alquilacion de 2-heteroaril-1,3-ditianos con bromuros bencilicos para dar heterocombretastatinas que por transformaciones sencillas da lugar a varios compuestos con sustitucion en el puente etilenico.  las heterolignanolidas han sido sintetizadas por adicion conjugada de 2-heteroaril-1,3-ditianos sobre 5h-furan-2-ona y alquilacion con aldehidos bencilicos. La transformacion de las lignanolidas en ciclolignananolidas y posteriores transformaciones da lugar a analogos heteroaromaticos de podofilotoxina.  se ha realizado la evaluacion de estos compuestos como antitumorales y antiparasitarios en los que algunos de los compuestos presentan actividad destacable.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y evaluacion de heterocombretastatinas, heterolignanolidas y compuestos relacionados.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y evaluacion de heterocombretastatinas, heterolignanolidas y compuestos relacionados. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angel Custodio Ramos Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Mearde Agustin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Grande Benito <\/li>\n<li>Francisco Palacios Gambra (vocal)<\/li>\n<li>Jos\u00e9 Vicente Sinisterra Gago (vocal)<\/li>\n<li>Enrique Guitian Rivera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angel Custodio Ramos Sanchez En este trabajo se ha realizado la sintesis y determinacion estructural de heterocombretastatinas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,17,416,9386],"tags":[249493,2802,33655,6641,4206,249494],"class_list":["post-135294","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-quimica","category-quimica-organica","category-salamanca","tag-angel-custodio-ramos-sanchez","tag-enrique-guitian-rivera","tag-francisco-palacios-gambra","tag-jose-vicente-sinisterra-gago","tag-manuel-grande-benito","tag-manuel-mearde-agustin"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/135294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=135294"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/135294\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=135294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=135294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=135294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}