{"id":135409,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variaciones-en-la-expresion-genica-en-el-rinon-durante-la-progresion-de-la-enfermedad-renal\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"variaciones-en-la-expresion-genica-en-el-rinon-durante-la-progresion-de-la-enfermedad-renal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/variaciones-en-la-expresion-genica-en-el-rinon-durante-la-progresion-de-la-enfermedad-renal\/","title":{"rendered":"Variaciones en la expresion genica en el ri\u00f1on durante la progresion de la enfermedad renal."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Macia Heras Manuel Luis <\/strong><\/h2>\n<p>En el presente trabajo estudiamos la expresion en biopsias renales, mediante pcr, genes que intervienen en procesos implicados en la progresion de la enfermedad renal a traves de su accion sobre la proliferacion crecimiento y diferenciacion celular, que ademas presentan interacciones entre si. Se estudiaron 16 pacientes, cuya indicacion de biopsia renal fue: sindrome nefrotico (sn;n=5); fracaso renal agudo (fra; n=4) y alteraciones urinarias asintomaticas (n=7). Los objetivos fueron: determinar la expresion de proto-oncogenes:  c-sis, c-fos, c-myc y c-erb-b2; de los genes que codifican endotelina: et-1. Determinar su expresion en la diferentes situaciones patologicas planteadas (hipertesion arterial, sn, fra, lupus eritematosos sistemico). Determinar la expresion de estos genes en funcion del grado de afectacion histologica. Los diagnosticos anatomo-patologicos se agruparon en funcion del caracter proliferativo (n=6) o no de las lesiones (n=10). De forma general nosotros hemos encontrado que los genes estudiados sufren variaciones en su expresion; no solo al comparar los pacientes con los controles, si no al analizar cada uno de los grupos estudiados. La expresion genica de et-1 en significativamente mayor en los pacientes con hta (p&lt;0.05). El analisis global de estos resultados nos permitio establecer, mediante regresion logistica, que tanto la aparicion de hta como de sn, entidades claramente implicadas en la progresion de la enfermedad renal, se ajustan a un modelo predictivo que es funcion de los genes estudiados (p&lt;0.05 para ambos modelos).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variaciones en la expresion genica en el ri\u00f1on durante la progresion de la enfermedad renal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variaciones en la expresion genica en el ri\u00f1on durante la progresion de la enfermedad renal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Macia Heras Manuel Luis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pablo Martin Vasallo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Hernandez Nieto <\/li>\n<li>Francisco Coronel Diaz (vocal)<\/li>\n<li>Carlos Hernandez Calzadilla (vocal)<\/li>\n<li>Santiago Suria Gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Macia Heras Manuel Luis En el presente trabajo estudiamos la expresion en biopsias renales, mediante pcr, genes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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