{"id":135579,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-funcion-linfocitaria-mediante-el-ifn-alfa\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"modulacion-de-la-funcion-linfocitaria-mediante-el-ifn-alfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-funcion-linfocitaria-mediante-el-ifn-alfa\/","title":{"rendered":"Modulacion de la funcion linfocitaria mediante el ifn alfa."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Llamas Huerta M. Estrella <\/strong><\/h2>\n<p>El ifn alfa es una citocina que juega un importante papel en la defensa del huesped frente a las infecciones, siendo ademas un agente antiproliferativo y antineoplasico, con capacidad para modular la diferenciacion celular y la funcion inmune. Para intentar comprender mejor este papel inmunorregulador analizamos su efecto en la expresion de dos moleculas de activacion celular, cd69 y cd25, determinando los niveles de calcio intracelular y la respuesta proliferativa. Encontramos un aumento tanto en el porcentaje como en la densidad de expresion del cd69 en aquellas celulas que han sido previamente tratadas con ifn alfa, observando una disminucion de dichos parametros en cuanto al cd25. Estos efectos no se acompa\u00f1an de cambios en los niveles de calcio intracelular. Ademas, el ifn alfa inhibe la proliferacion celular tras la estimulacion con pha a nivel de la fase s del ciclo celular. Finalmente, dada la relativa peligrosidad que entra\u00f1a el uso de material radioactivo, concluimos que existen metodos alternativos para analizar la proliferacion celular con resultados totalmente fiables.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion de la funcion linfocitaria mediante el ifn alfa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion de la funcion linfocitaria mediante el ifn alfa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Llamas Huerta M. Estrella <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Conde Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ramon Perez Cano <\/li>\n<li>Antonio Basomba Riva (vocal)<\/li>\n<li>Jos\u00e9 Antonio Dur\u00e1n Quintana (vocal)<\/li>\n<li>Carlos Martinez Manzanares (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Llamas Huerta M. Estrella El ifn alfa es una citocina que juega un importante papel en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1957,9,156,10715],"tags":[249819,1664,26649,1961,249818,10783],"class_list":["post-135579","post","type-post","status-publish","format-standard","hentry","category-alergias","category-ciencias-medicas","category-patologia","category-sevilla","tag-antonio-basomba-riva","tag-carlos-Martinez-manzanares","tag-jose-antonio-duran-quintana","tag-jose-conde-hernandez","tag-llamas-huerta-m-estrella","tag-ramon-perez-cano"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/135579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=135579"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/135579\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=135579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=135579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=135579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}