{"id":135628,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-un-nuevo-autoantigeno-mediante-la-produccion-de-anticuerpos-monoclonales-humanos\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"identificacion-de-un-nuevo-autoantigeno-mediante-la-produccion-de-anticuerpos-monoclonales-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/identificacion-de-un-nuevo-autoantigeno-mediante-la-produccion-de-anticuerpos-monoclonales-humanos\/","title":{"rendered":"Identificacion de un nuevo autoantigeno mediante la produccion de anticuerpos monoclonales humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Tarrago Asensio <\/strong><\/h2>\n<p>Una de las caracteristicas esenciales de las enfermedades autoinmunes es la presencia en el suero de los pacientes de anticuerpos que reaccionan frente a moleculas propias.  en el presente trabajo hemos utilizado linfocitos b procendentes de una paciente con esclerodermia, para generar dos anticuerpos monclonales humanos (acmo) distintos capaces de reconocer un autoantigeno desconocido, el acmo b-24 con un patron de union como el descrito para los anticuerpos polireactivos y el acmo b-33 monoespecifico. Frente a este autoantigeno tambien reaccionaban cinco sueros procedentes de pacientes con diversas manifestaciones autoinmunes. Investigando la naturaleza del compartimento celular reconocido mediante inmunofluorescencia y microscopia electronica, pudimos asignar al endosoma tardio como diana de estos autoanticuerpos. Por otra parte, y tras la secuenciacion del extremo amino terminal del antigeno purificado por cromatografia de afinidad con el acmo b-33, se identifico mediante busqueda por homolog\u00eda de secuencia en una base de datos este nuevo autoantigeno, que resulto ser el receptor de la manosa 6-fosfato independiente de calcio (ci-mpr). La generacion de anticuerpos monoclonales humanos nos permitio por tanto, no solo estudiar con todo detalle la biolog\u00eda de la organela diana, sino tambien el aislamiento y purificacion de este nuevo autoantigeno para su porterior identificacion y estudio molecular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificacion de un nuevo autoantigeno mediante la produccion de anticuerpos monoclonales humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificacion de un nuevo autoantigeno mediante la produccion de anticuerpos monoclonales humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Tarrago Asensio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Berta Sanchez Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Gregorio Garc\u00eda Herdugo <\/li>\n<li>Manuel Santamaria Ossorio (vocal)<\/li>\n<li>Ines Martin Lacave (vocal)<\/li>\n<li>Jos\u00e9 Manuel Martin Villa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Tarrago Asensio Una de las caracteristicas esenciales de las enfermedades autoinmunes es la presencia en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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