{"id":135714,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-in-vitro-de-la-influencia-del-acido-lactico-acido-glicolico-y-laurilsulfato-sodico-en-la-permeabilidad-de-la-piel-humana\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-in-vitro-de-la-influencia-del-acido-lactico-acido-glicolico-y-laurilsulfato-sodico-en-la-permeabilidad-de-la-piel-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-in-vitro-de-la-influencia-del-acido-lactico-acido-glicolico-y-laurilsulfato-sodico-en-la-permeabilidad-de-la-piel-humana\/","title":{"rendered":"Estudio \u00abin vitro\u00bb de la influencia del acido lactico, acido glicolico y laurilsulfato sodico en la permeabilidad de la piel humana."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alfonso Copovi Carrion <\/strong><\/h2>\n<p>Se determina, mediante un metodo \u00abin vitro\u00bb, el efecto promotor de la penetracion a traves de la piel humana desarrollado por dos alfa-hidroxiacidos (acido glicolico y acido lactico), y un tensiactivo (laurilsulfato sodico). Estas sustancias intervienen frecuentemente como coadyuvantes en la elaboracion de preparados dermatologicos.  se han seleccionado, como sustancias penetrantes, cuatro compuestos que, en conjunto, abarcan un amplio ambito de lipofilia, 5-fluoruracilo, 2-feniletanol, 4-fenilbutanol y 5-fenilpentanol.  el estudio se complementa con pruebas de irritacion primaria de las sustancias estudiadas como promotores y a las concentraciones utilizadas en el trabajo.  se demuestra que el tratamiento de la piel humana con acido lactico, acido glicolico y laurilsulfato sodico incrementa su permeabilidad para los compuestos cuya lipofilia, expresada como coeficiente de reparto en n-octanol, es inferior a 776.  el efecto de los alfa-hidroxiacidos se atribuye a sus propiedades higroscopicas que al incrementar la capacidad de retencion de agua de la piel, facilitan la penetracion de las moleculas mas hidrofilas.  el efecto del tensiactivo (laurilsulfato sodico) se atribuye a dos mecanismos de accion simultaneos: un efecto fluidificante de los lipidos cutaneos, y un aumento de la capacidad de hidratacion de la membrana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio \u00abin vitro\u00bb de la influencia del acido lactico, acido glicolico y laurilsulfato sodico en la permeabilidad de la piel humana.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio \u00abin vitro\u00bb de la influencia del acido lactico, acido glicolico y laurilsulfato sodico en la permeabilidad de la piel humana. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alfonso Copovi Carrion <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marina Herraez Dominguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Victor Jimenez Torres <\/li>\n<li>M\u00aa Antonia Camacho S\u00e1nchez (vocal)<\/li>\n<li>Diego M. Cortes Mart\u00ednez (vocal)<\/li>\n<li> Ygartua Ayerra M. Pilar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alfonso Copovi Carrion Se determina, mediante un metodo \u00abin vitro\u00bb, el efecto promotor de la penetracion a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,9,189],"tags":[249982,2514,3310,27321,3309,185988],"class_list":["post-135714","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","tag-alfonso-copovi-carrion","tag-diego-m-cortes-Martinez","tag-marina-herraez-dominguez","tag-ma-antonia-camacho-sanchez","tag-victor-jimenez-torres","tag-ygartua-ayerra-m-pilar"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/135714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=135714"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/135714\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=135714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=135714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=135714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}