{"id":135737,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-terapeutico-de-5-asa-y-del-efecto-preventivo-y-terapeutico-de-acz-sobre-las-lesiones-inducidas-por-tnb-en-el-colon-de-la-rata\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-del-efecto-terapeutico-de-5-asa-y-del-efecto-preventivo-y-terapeutico-de-acz-sobre-las-lesiones-inducidas-por-tnb-en-el-colon-de-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-terapeutico-de-5-asa-y-del-efecto-preventivo-y-terapeutico-de-acz-sobre-las-lesiones-inducidas-por-tnb-en-el-colon-de-la-rata\/","title":{"rendered":"Estudio del efecto terapeutico de 5-asa y del efecto preventivo y terapeutico de acz sobre las lesiones inducidas por tnb en el colon de la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Fernandez Martinez <\/strong><\/h2>\n<p>Introduccion: el acido 2,4,6-trinitrobenzensulfonico (tnb) induce una colitis experimental que remeda la histolog\u00eda de la enfermedad inflamatoria intestinal.Los objetivos del estudio son: valorar la eficacia terapeutica de 5-asa en la colitis por tnb, y estudiar el posible efecto en la prevencion y el tratamiento de esta colitis del acexamato de zn (acz) -un antiulceroso protector de mucosa-.Material y metodo: 287 ratas wistar macho (140-180 g) fueron lesionadas con tnb y adscritas previamente a tres protocolos: a) tratamiento via rectal, que incluyo un grupo control, un grupo 5-asa y uno acz; b) protocolo de profilaxis via rectal, con un grupo control y otro acz; y c) protocolo de profilaxis via oral, con un grupo control y otro acz. Se evaluaron los efectos de los tratamientos sobre las lesiones en periodos que oscilaron entre 24 h minimo, y un maximo de 4 semanas, mediante: medicion de diferencia de potencial transmucoso, grados de lesion macroscopica y microscopica y actividad enzimatica de mieloperoxidasa.  resultados: 1) 5-asa y acz reducen por igual las lesiones inducidas por tnb. Este efecto se observa a partir de la 3 semana. 2) acz administrado como enema profilactico, previene las lesiones colicas inducidas por tnb. 3) acz administrado como profilaxis via oral en dosis crecientes, reduce las lesiones por tnb a las dos semanas de evolucion. 4) se confirma el valor de la diferencia de potencial transmucoso como indicador de lesion aguda y cronica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto terapeutico de 5-asa y del efecto preventivo y terapeutico de acz sobre las lesiones inducidas por tnb en el colon de la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto terapeutico de 5-asa y del efecto preventivo y terapeutico de acz sobre las lesiones inducidas por tnb en el colon de la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Fernandez Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Salvador Lledo Matoses<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Carbonell Antoli <\/li>\n<li>Fernando Gomollon Garcia (vocal)<\/li>\n<li>Alberto Gomez Alonso (vocal)<\/li>\n<li>Miguel Minguez Perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Fernandez Martinez Introduccion: el acido 2,4,6-trinitrobenzensulfonico (tnb) induce una colitis experimental que remeda la histolog\u00eda de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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