{"id":135804,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-in-vitro-de-la-absorcion-percutanea-de-una-serie-de-fenil-alcoholes-y-su-influencia-en-la-penetracion-del-5-fluorouracilo\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-in-vitro-de-la-absorcion-percutanea-de-una-serie-de-fenil-alcoholes-y-su-influencia-en-la-penetracion-del-5-fluorouracilo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-in-vitro-de-la-absorcion-percutanea-de-una-serie-de-fenil-alcoholes-y-su-influencia-en-la-penetracion-del-5-fluorouracilo\/","title":{"rendered":"Estudio \u00abin vitro\u00bb de la absorcion percutanea de una serie de fenil alcoholes y su influencia en la penetracion del 5-fluorouracilo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alicia Cristina L\u00f3pez Castellano <\/strong><\/h2>\n<p>El trabajo constituye una aportacion al conocimiento de los factores que condicionan la penetracion de sustancias a traves de la piel. Con este fin, se han determinado, mediante dos metodos \u00abin vitro\u00bb de dosis infinita (soluciones y suspensiones de los penetrantes) los coeficientes de permeabilidad, kp, a traves de epidermis de rata wistar, de varios elementos pertenecientes a una serie de fenil alcoholes. Se establecen correlaciones penetracion\/lipofilia y se comparan entre si y con las obtenidas anteriormente, con otras series de compuestos.  los resultados permiten demostrar:  a) para determianr el coeficiente de permeabilidad, parametro que caracteriza la capacidad de los compuestos para difundir a traves de la piel, es necesario prolongar los ensayos de difusion \u00abin vitro\u00bb mas de un dia. Solo de este modo se alcanza el estado estacionario de la difusion necesario para determinar kp.  b) el modelo que define la penetracion de los compuestos a traves de la piel, en todos los casos analizados, corresponde a un modelo probabilistico (bilineal), que caracteriza a la piel como un sistema multifasico, con un valor optimo de lipofilia para la penetracion, correspondiente a un compuesto que poseyera un valor de coeficiente de reparto, p, expresado como log p= 3.1. Si este hecho llegara a confirmarse mediante estudios \u00abin vivo\u00bb, seria de gran interes en la seleccion o dise\u00f1o de farmacos candidatos a la aplicacion transdermica.  c) el 2-feniletanol, el 3-fenilpropanol y el cinamil alcohol se comportan como promotores de la penetracion cutanea del 5-fluorouracilo, farmaco antimitotico. Esta accion se debe a un efecto directo sobre el grado de ordenacion de los lipidos de las estructuras cutaneas como se demuestra a partir del analisis de las isotermas de presion supercial \/area molecular en monocapas constituidas por mezclas de dipalmitoilfosfatidilcolina y los fenilalcoholes estudiados. Estos fenilalcoholes intervienen frecuentemen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio \u00abin vitro\u00bb de la absorcion percutanea de una serie de fenil alcoholes y su influencia en la penetracion del 5-fluorouracilo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio \u00abin vitro\u00bb de la absorcion percutanea de una serie de fenil alcoholes y su influencia en la penetracion del 5-fluorouracilo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alicia Cristina L\u00f3pez Castellano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marina Herraez Dominguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Victor Jimenez Torres <\/li>\n<li>Julio Cortijo Gimeno (vocal)<\/li>\n<li>Jos\u00e9 Luis Vila Jato (vocal)<\/li>\n<li>Esther Sanchez Sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alicia Cristina L\u00f3pez Castellano El trabajo constituye una aportacion al conocimiento de los factores que condicionan la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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