{"id":135976,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-un-farmaco-mucomimetico-como-sustituto-de-la-capa-mucosa-de-la-pelicula-lagrimal\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"desarrollo-de-un-farmaco-mucomimetico-como-sustituto-de-la-capa-mucosa-de-la-pelicula-lagrimal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-de-un-farmaco-mucomimetico-como-sustituto-de-la-capa-mucosa-de-la-pelicula-lagrimal\/","title":{"rendered":"Desarrollo de un farmaco mucomimetico como sustituto de la capa mucosa de la pelicula lagrimal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Argueso Gonzalez <\/strong><\/h2>\n<p>En este trabajo de investigacion se han caracterizado parcialmente las mucinas de la capa mucosa de la pelicula lagrimal humana con el objetivo de desarrollar un farmaco mucomimetico con sus mismas caracteristicas fisico-quimicas. Este sustituto artificial podria ser utilizado en el tratamiento de tres situaciones clinicas:  1) en los efectos adversos de los farmacos sobre la superficie ocular, 2) en el sindrome de ojo seco asociado a una deficiencia de la capa mucosa y 3) en la vehiculizacion de los principios activos de los farmacos para aumentar su tiempo de residencia sobre la superficie ocular. Los resultados han mostrado que las mucinas oculares estan recubiertas de acido sialico; un carbohidrato que las confiere carga electrica negativa y que podria favorecer la baja tension superficial del moco ocular. Tambien se han detectado estructuras tipo quitina en las mucinas oculares. En base ha estos resultados se han identificado dos polimeros en cuya estructura existen enlaces comunes a las mucinas, el acido colominico y el quitosano o quitina parcialmente deacetilada. Este ultimo es un biopolimero natural que esta siendo actualmente utilizado en una amplia variedad de aplicaciones biomedicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de un farmaco mucomimetico como sustituto de la capa mucosa de la pelicula lagrimal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de un farmaco mucomimetico como sustituto de la capa mucosa de la pelicula lagrimal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Argueso Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Tomas Girbes Juan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Pastor Jimeno <\/li>\n<li>Jos\u00e9 Vaquera Orte (vocal)<\/li>\n<li>Juan Murube Del Castillo (vocal)<\/li>\n<li>Josep Guasch Rosello (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Argueso Gonzalez En este trabajo de investigacion se han caracterizado parcialmente las mucinas de la capa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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