{"id":13632,"date":"2001-05-11T00:00:00","date_gmt":"2001-05-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/derivados-pirimida%c2%adnicos-modulares-de-funciones-leucocitarias-en-la-respuesta-inflamatoria\/"},"modified":"2001-05-11T00:00:00","modified_gmt":"2001-05-11T00:00:00","slug":"derivados-pirimida%c2%adnicos-modulares-de-funciones-leucocitarias-en-la-respuesta-inflamatoria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/derivados-pirimida%c2%adnicos-modulares-de-funciones-leucocitarias-en-la-respuesta-inflamatoria\/","title":{"rendered":"Derivados pirimid\u00ednicos modulares de funciones leucocitarias en la respuesta inflamatoria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Amparao Vidal Mengual <\/strong><\/h2>\n<p>En esta tesis doctoral se ha estudiado la actividad de tres series de derivados pirimid\u00ednicos de s\u00edntesis (imidazopirimidinas, hexahidroimidazopirimidinas y isoxazolpirimidinas) sobre diversas dianas farmacol\u00f3gicas implicadas en el desarrollo del proceso inflamatorio. Se han realizado ensayos enmacr\u00f3fagos peritoneales de rat\u00f3n, neutr\u00f3filos humanos y enximas aisladas. Tambi\u00e9n se ha trabajado con los modelos in vivo de \u00abbolsa de aire\u00bb, edema plantar y edema en oreja en rat\u00f3n. Se ha demostrado que varios componentes de las series de los imidazopirimidinas y hexahidroimidazopirimidinas han presentado un buen perfil farmacol\u00f3gico como inhibidores de la activaci\u00f3n neutrof\u00edlica, la producci\u00f3n de \u00f3xido n\u00edtrico por macr\u00f3fagos peritoneales de rat\u00f3n y la migraci\u00f3n leucocitaria en modelos in vivo. El derivado con un perfil farmacol\u00f3gico m\u00e1s interesante dentro de estas dos series, es la hexahidroimidazopirimidina-4 por presentar actividad antiinflamatoria por v\u00eda oral en el edema inducido por carragenina; adem\u00e1s in vivo, inhibe la migaraci\u00f3n leucocitaria tanto administrado por v\u00eda oral como a nivel local. En la serie de derivados isoxazolpirimid\u00ednicos, en la que se han estudiado 12 compuestos, cuatro de ellos han inhibido la producci\u00f3n de \u00f3xido n\u00edtrico y pge2 en macr\u00f3fagos peritoneales de rat\u00f3n, con unas ci50 en el rango micromolar. Adem\u00e1s, los derivados 4 y 5 han reducido la expresi\u00f3n proetica de nosi y de cox-2, respectivamente. Los derivados 1,4 y 5 han corroborado su actividad sobre la bios\u00edntesis de \u00f3xido n\u00edtrico en el modelo de \u00abbolsa de aire\u00bb en rat\u00f3n adminsitrados por v\u00eda oral. Por ese motivo, estos derivados podr\u00edan presentar un buen perfil farmacol\u00f3gico para el control de patolog\u00edas que cursan con un exceso de producci\u00f3n de \u00f3xido n\u00edtrico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Derivados pirimid\u00ednicos modulares de funciones leucocitarias en la respuesta inflamatoria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Derivados pirimid\u00ednicos modulares de funciones leucocitarias en la respuesta inflamatoria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Amparao Vidal Mengual <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ferrandiz Manglano M. Luisa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: diego m. Cortes mart\u00ednez <\/li>\n<li>Jos\u00e9 Sep\u00falveda arques (vocal)<\/li>\n<li> De la puerta vazques rocio (vocal)<\/li>\n<li> De las heras polo beatriz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amparao Vidal Mengual En esta tesis doctoral se ha estudiado la actividad de tres series de derivados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,189,957,483],"tags":[44197,44198,44199,2514,26888,27464],"class_list":["post-13632","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacodinamia","category-farmacologia","category-mecanismos-de-accion-de-los-farmacos","tag-amparao-vidal-mengual","tag-de-la-puerta-vazques-rocio","tag-de-las-heras-polo-beatriz","tag-diego-m-cortes-Martinez","tag-ferrandiz-manglano-m-luisa","tag-jose-sepulveda-arques"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13632"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13632\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}