{"id":136399,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-farmacologica-de-la-respuesta-inmunologica-en-la-sepsis-quirurgica\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"modulacion-farmacologica-de-la-respuesta-inmunologica-en-la-sepsis-quirurgica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-farmacologica-de-la-respuesta-inmunologica-en-la-sepsis-quirurgica\/","title":{"rendered":"Modulacion farmacologica de la respuesta inmunologica en la sepsis quirurgica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fel\u00edcito Garc\u00eda-alvarez Garc\u00eda <\/strong><\/h2>\n<p>Introduccion: se constata con frecuencia que a procesos infecciosos o a grandes traumatismos les sucede la aparicion de shock septico y fracaso multiorganico (fmo).  una desmesurada respuesta del sistema inmunologico ha sido implicada en estas complicaciones. Los radicales libres son causa y consecuencia de la liberacion de citoquinas. De hecho, los radicales del oxigeno aumentan la produccion de il-1 y tnf mediante activacion del factor de transcripcion nuclear (nfkb) (grimble, 1994).  el metamizol, es un farmaco anti-inflamatorio no esteroideo (aine) ampliamente usado como analgesico en los pacientes quirurgicos, que inhibe la ciclo-oxigenasa y por tanto la produccion de pge2 (luthy et al, 1983). Se sabe ademas, que algunos aines inhiben al nfkb (pierce et al, 1996). La s-adenosil metionina (same) aumenta el contenido de glutation en el hepatocito y protege a las celulas del efecto de los radicales libres. Este estudio pretende valorar el efecto del metamizol y la same sobre la respuesta inmunologica en un modelo experimental de sepsis quirurgica. Material: 30 ratas macho w-f de 300-350 g. Se dividieron en 3 grupos: grupo a (control):  se sometio a anestesia intramuscular (i.M.) Y se realizo laparotomia con ligadura y puncion del ciego (clp). Grupo b (sepsis + metamizol): clp + una dosis i.M. De 229 mg\/kg de same los dias 1. (Ipo) y 2. (2po). Una semana antes de la intervencion (pre) y los dias 1 (1po) y 3 (3po) post-intervencion fueron determinados en sangre periferica: porcentajes de celulas cd3, cd4, cd8, y de il-2r (por citometria de flujo usando moab) y niveles de il-1, il-2, il-4, il-6, il-10 y tnf (elisa y moab).  resultados: en el grupo a se observo: un descenso significativo del %cd3, %cd4 y del %cd8; mientras que se observo un ascenso de todas las citoquinas estudiadas, excepto la il-2 que descendio en el 3po, siendo estadisticamente significativa solo la variacion de la il-1. En el grupo b: la il-1 mostro un discre<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion farmacologica de la respuesta inmunologica en la sepsis quirurgica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion farmacologica de la respuesta inmunologica en la sepsis quirurgica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fel\u00edcito Garc\u00eda-alvarez Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Navarro Zorraquino<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ricardo Lozano Mantecon <\/li>\n<li> De Pedro Moro Jos\u00e9 Antonio (vocal)<\/li>\n<li>Jos\u00e9 Bueno G\u00f3mez (vocal)<\/li>\n<li>Luis Larrad Mur (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fel\u00edcito Garc\u00eda-alvarez Garc\u00eda Introduccion: se constata con frecuencia que a procesos infecciosos o a grandes traumatismos les [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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