{"id":136436,"date":"2026-01-12T16:56:50","date_gmt":"2026-01-12T16:56:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/toxicidad-de-heroina-metadona-y-cocaina-para-hepatocitos-humanos-influencia-de-etanol-y-diazepan\/"},"modified":"2026-01-12T16:56:50","modified_gmt":"2026-01-12T16:56:50","slug":"toxicidad-de-heroina-metadona-y-cocaina-para-hepatocitos-humanos-influencia-de-etanol-y-diazepan","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/toxicidad-de-heroina-metadona-y-cocaina-para-hepatocitos-humanos-influencia-de-etanol-y-diazepan\/","title":{"rendered":"Toxicidad de heroina, metadona y cocaina para hepatocitos humanos: influencia de etanol y diazepan"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ponsoda Marti Xavier Josep <\/strong><\/h2>\n<p>Se ha realizado un estudio para evaluar el efecto toxico de estas tres sustancias para los hepatocitos humanos en cultivo midiendo cambios en la viabilidad celular y en las funciones metabolicas mas importantes del hepatocito.  con los resultados aqui obtenidos y los valores de concentracion plasmatica alcanzados tras la administracion de las drogas se han calculado los riesgos de toxicidad respectivos. Empleando este modelo biologico, reproduciendo en la medida de lo posible las circunstancias que se dan en los drogadictos, se ha evaluado la posible interaccion toxicologica entre estas tres drogas y el etanol y el diazepan. A partir de los resultados obtenidos, las conclusiones mas importantes obtenidas son: las tres drogas afectan a la viabilidad y a las funciones metabolicas mas importantes de los hepatocitos humanos en cultivo; el orden de toxicidad molar es: metadonas heroina cocaina; los riesgos de toxicidad (rt) de las tres drogas tras dosis de abuso son elevados y la metadona presenta rt elevado tras dosis terapeuticas; el etanol potencia la toxicidad de estas drogas; y no se ha encontrado interaccion con el diaz.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Toxicidad de heroina, metadona y cocaina para hepatocitos humanos: influencia de etanol y diazepan<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Toxicidad de heroina, metadona y cocaina para hepatocitos humanos: influencia de etanol y diazepan <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ponsoda Marti Xavier Josep <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>lech\u00f3n Moliner G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Cabo Soler <\/li>\n<li>Mar\u00eda Del Prado M\u00edguez Santiy\u00e1n (vocal)<\/li>\n<li>Jes\u00fas Vazquez Garcia (vocal)<\/li>\n<li>Joaquin Berenguer Lapuerta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ponsoda Marti Xavier Josep Se ha realizado un estudio para evaluar el efecto toxico de estas tres [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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