{"id":136555,"date":"2026-01-12T16:58:18","date_gmt":"2026-01-12T16:58:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hepatoxicidad-de-los-estrogenos-estudio-experimental\/"},"modified":"2026-01-12T16:58:18","modified_gmt":"2026-01-12T16:58:18","slug":"hepatoxicidad-de-los-estrogenos-estudio-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/hepatoxicidad-de-los-estrogenos-estudio-experimental\/","title":{"rendered":"Hepatoxicidad de los estrogenos: estudio experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mu\u00f1oz Rodriguez Luis Jose <\/strong><\/h2>\n<p>Se administra valerianato de estradiol (s. C.) A ratas wistar hembra durante 3, 6 y 9 meses. Se valoro una serie de parametros sericos (glucosa, lipidos, bilirrubina, fosfatasa alcalina y transaminasas) asi como el estudio morfologico, incluyendo ultraestructura del higado, todo ello con objeto de valorar los cambios que los estrogenos pueden inducir a nivel hepatico. Se realizo contaje de jepatocitos a nivel periportal y pericentral, y en estos dos niveles tambien se midio el diametro de los sinusoides. De nuestros resultados deducimos que la administracion prolongada de estradiol en la rata indujo hipotriglicerinemia, hipercolesterinemia, datos de moderada citolisis con la dosis alta, sin detectar colestasis. Se pudo demostrar dilatacion sinusoidal, y en un caso un hallazgo compatible con peliosis. No se ha demostrado claras alteraciones ultraestructurales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hepatoxicidad de los estrogenos: estudio experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hepatoxicidad de los estrogenos: estudio experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mu\u00f1oz Rodriguez Luis Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agustin Caro Paton Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Olegario Ortiz Manchado <\/li>\n<li> Coca Garcia Mar\u00eda  Cruz (vocal)<\/li>\n<li>Luis Rodrigo Saez (vocal)<\/li>\n<li>Ramon Perez Alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mu\u00f1oz Rodriguez Luis Jose Se administra valerianato de estradiol (s. C.) A ratas wistar hembra durante 3, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,12451],"tags":[9694,9408,9097,250985,27831,45927],"class_list":["post-136555","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-valladolid","tag-agustin-caro-paton-gomez","tag-coca-garcia-maria-cruz","tag-luis-rodrigo-saez","tag-munoz-rodriguez-luis-jose","tag-olegario-ortiz-manchado","tag-ramon-perez-alvarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/136555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=136555"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/136555\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=136555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=136555"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=136555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}