{"id":13657,"date":"2001-06-11T00:00:00","date_gmt":"2001-06-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/induccion-de-apoptosis-por-citotoxicos-en-macrofagos-y-celulas-dependientes-de-interleuquina-3\/"},"modified":"2001-06-11T00:00:00","modified_gmt":"2001-06-11T00:00:00","slug":"induccion-de-apoptosis-por-citotoxicos-en-macrofagos-y-celulas-dependientes-de-interleuquina-3","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/induccion-de-apoptosis-por-citotoxicos-en-macrofagos-y-celulas-dependientes-de-interleuquina-3\/","title":{"rendered":"Inducci\u00f3n de apoptosis por citot\u00f3xicos en macr\u00f3fagos y c\u00e9lulas dependientes de interleuquina-3"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gemma Olmos Centenera <\/strong><\/h2>\n<p>En el presente trabajo de tesis doctoral se han estudiado las acciones de dos sustancias antitumorales en c\u00e9lulas macrof\u00e1gicas, de m\u00e9dula \u00f3sea y de linfoma de rat\u00f3n y su modulaci\u00f3n por interleuquina 3.  el objeto del mismo ha sido dise\u00f1ar estrategias que induzcan selectivamente apoptosis en las c\u00e9lulas tumorales y aumentar la resitencia de las c\u00e9lulas sanas por inhibici\u00f3n de su potencial apot\u00f3tico mediante el empleo de un factor de crecimiento como es interleuquina 3.  teniendo en cuenta estos aspectos se han planteado los siguientes objetivos:  a,- desarrollar un modelo de transporte y direccionalizaci\u00f3n selectivos de factores de crecimiento hacia c\u00e9lulas del sistema inmune (concretamente a macr\u00f3fagos peritoneales), empleando un sistema fisiol\u00f3gico como son los eritrocitos. Con ello se busca hacer m\u00e1s eficaces los tratamientos antitumorales tanto en su acci\u00f3n como en la recuperaci\u00f3n celular.  b,- profundizar en los mecanismos de muerte celular que inducen los agentes citot\u00f3xicos utilizados en la terapia antitumoral, as\u00ed como la recuperaci\u00f3n por parte de factores de crecimiento sobre c\u00e9lulas del sistema inmune (macr\u00f3fagos peritoneales) y sobre dos tipos celulares dependientes de interleuquina-3; c\u00e9lulas procedentes de m\u00e9dula \u00f3sea de rat\u00f3n y de linfoma de rat\u00f3n.  las conclusiones obtenidas en este trabajo se resumen en;  i,- los eritrocitos pueden incorporar en su interior interleuquina-3 mediante el m\u00e9todo de di\u00e1lisis hipot\u00f3nica y ser modificados en su membrana con el reactivo bifuncional bs3, obteni\u00e9ndose un alto rendimiento celular.  ii,- los macr\u00f3fagos peritoneales de rat\u00f3n reconocen a los eritrocitos con interleuquina-3 encapsulada y modificados con bs3 en un porcentaje aproximado del 60%. Esta interacci\u00f3n puede estar favorecida e incrementada por la presencia de il-3 en la membrana de la c\u00e9lula roja.  iii,- il-3 ejerce un efecto directo sobre macr\u00f3fagos observado en la fosforilaci\u00f3n de pro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inducci\u00f3n de apoptosis por citot\u00f3xicos en macr\u00f3fagos y c\u00e9lulas dependientes de interleuquina-3<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inducci\u00f3n de apoptosis por citot\u00f3xicos en macr\u00f3fagos y c\u00e9lulas dependientes de interleuquina-3 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gemma Olmos Centenera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos Diez Ballesteros<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Luque cabrera <\/li>\n<li>mary Collins (vocal)<\/li>\n<li>margarita Lorenzo balado (vocal)<\/li>\n<li>Francisco Wandosell jurado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gemma Olmos Centenera En el presente trabajo de tesis doctoral se han estudiado las acciones de dos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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