{"id":136740,"date":"2026-01-12T17:00:02","date_gmt":"2026-01-12T17:00:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificaciones-farmacocineticas-de-un-farmaco-acido-sulfametazina-inducidas-por-el-acto-quirurgico\/"},"modified":"2026-01-12T17:00:02","modified_gmt":"2026-01-12T17:00:02","slug":"modificaciones-farmacocineticas-de-un-farmaco-acido-sulfametazina-inducidas-por-el-acto-quirurgico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modificaciones-farmacocineticas-de-un-farmaco-acido-sulfametazina-inducidas-por-el-acto-quirurgico\/","title":{"rendered":"Modificaciones farmacocineticas de un farmaco acido (sulfametazina) inducidas por el acto quirurgico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sebastian Sarabia Garcia <\/strong><\/h2>\n<p>Introduccion: se repasan resumidamente los principios basico de la farmacocinetica, asi como la fisiolog\u00eda gastrica y las tecnicas quirurgicas, frecuentemente usadas en la ulcera gastro-duodenal. Definidas las tecnicas de laboratorio, grupo control de voluntarios sanos en los que se realizo una farmacocinetica global con sulfametazina (oral e intravenosa), y el grupo de pacientes intervenidos quirurgicamente con perdida de mucosa y sin perdida de mucosa, se pasa a evaluar los resultados obtenidos en absorcion, distribucion y eliminacion del farmaco en ambos grupos. En los resultados obtenidos con el grupo control se demuestra, que la farmacocinetica no es lineal para este farmaco, existen variaciones en los parametros y constantes, tanto de la absorcion, distribucion y eliminacion; y no se puede calcular la biodisponibilidad con el metodo clasico del cociente entre las areas bajo la curva trasoral e intravenosa. Con estos resultados y eliminados estas causas de error, se practica farmacocinetica oral en los pacientes operados con denervacion gastrica, mas drenaje o perdida de mucosa, objetivandose alteraciones en los resecados gastricos, cuyo efecto clinico, se traduce en que estos individuos no alcanzarian dosis terapeuticas eficaces, en el estado de equilibrio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaciones farmacocineticas de un farmaco acido (sulfametazina) inducidas por el acto quirurgico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaciones farmacocineticas de un farmaco acido (sulfametazina) inducidas por el acto quirurgico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sebastian Sarabia Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosario Calvo Duo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alfonso Moreno Gonzalez <\/li>\n<li>Raimundo Carlos Garcia (vocal)<\/li>\n<li>Jos\u00e9 Hernandez Calvo (vocal)<\/li>\n<li>Rafael Martinez Jorda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sebastian Sarabia Garcia Introduccion: se repasan resumidamente los principios basico de la farmacocinetica, asi como la fisiolog\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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