{"id":13697,"date":"2001-09-11T00:00:00","date_gmt":"2001-09-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-pronosticos-en-las-precancerosis-laringeas-valoracion-mediante-inmunohistoqua%c2%admica\/"},"modified":"2001-09-11T00:00:00","modified_gmt":"2001-09-11T00:00:00","slug":"factores-pronosticos-en-las-precancerosis-laringeas-valoracion-mediante-inmunohistoqua%c2%admica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/factores-pronosticos-en-las-precancerosis-laringeas-valoracion-mediante-inmunohistoqua%c2%admica\/","title":{"rendered":"Factores pron\u00f3sticos en las precancerosis laringeas: valoraci\u00f3n mediante inmunohistoqu\u00edmica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Galvez Pacheco <\/strong><\/h2>\n<p>Las lesiones precancerosas de laringe constituyen una patolog\u00eda que aun hoy d\u00eda entra\u00f1a dificultades diagn\u00f3sticas, pronosticas y terap\u00e9uticas.  califano, establece un modelo que relaciona las alteraciones morfol\u00f3gicas con el sustrato gen\u00e9tico, destacando una serie de cromosomas que albergan distintos marcadores (p53, ki-67, bcl-2 y cerbb-2), sin que ello signifique, en ning\u00fan caso, que la clave de la precancerosis laringea reside exclusivamente en estos marcadores, ya que existen aun muchas discrepancias al respecto.  adem\u00e1s, lo que le interesa al cl\u00ednico es poder transmitirle a un paciente con una lesi\u00f3n precancerosa el riesgo individual que tiene de contraer un c\u00e1ncer. Esto es el gran reto de la oncolog\u00eda moderna, y hasta hoy no se ha realizado en laringe.  realizamos un estudio inmunohistoqu\u00edmico de los marcadores p53 ki-67, bcl-2 y cerbb-2 en 285 lesiones precancerosas de laringe distribuidas de la siguiente manera: 91 displasia leve, 83 displasias moderadas, 51 displasia severa y 60 carcinomas \u00abin situ\u00bb.  en el tratamiento estad\u00edstico aplicamos por un lado un an\u00e1lisis univariante y por otro un an\u00e1lisis multivariante mediante la regresi\u00f3n m\u00faltiple de cox, que permite crear grupos de riesgo individual.  hemos determinado el papel de estos marcadores en la carcinogenesis laringea, su interrelaci\u00f3n con los factores de riesgo cl\u00e1sicos y por \u00faltimo, establecimos un modelo de calculo de riesgo individual, aplicable en la consulta cl\u00ednica diaria.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores pron\u00f3sticos en las precancerosis laringeas: valoraci\u00f3n mediante inmunohistoqu\u00edmica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores pron\u00f3sticos en las precancerosis laringeas: valoraci\u00f3n mediante inmunohistoqu\u00edmica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Galvez Pacheco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eulalia Bernet Vegu\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Pe\u00f1a Martinez <\/li>\n<li>alfredo Jurado ramos (vocal)<\/li>\n<li>Rafael Cano mu\u00f1oz (vocal)<\/li>\n<li>Fernando Guallart domenech (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Galvez Pacheco Las lesiones precancerosas de laringe constituyen una patolog\u00eda que aun hoy d\u00eda entra\u00f1a dificultades [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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