{"id":13710,"date":"2001-09-11T00:00:00","date_gmt":"2001-09-11T00:00:00","guid":{"rendered":""},"modified":"2001-09-11T00:00:00","modified_gmt":"2001-09-11T00:00:00","slug":"valor-del-inmunofenotipo-y-del-analisis-del-contenido-de-adn-por-citometria-de-flujo-en-la-investigacion-de-enfermedad-ma%c2%adnima-residual-en-pacientes-con-mieloma-multiple-sometidos-a-quimioterapia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-del-inmunofenotipo-y-del-analisis-del-contenido-de-adn-por-citometria-de-flujo-en-la-investigacion-de-enfermedad-ma%c2%adnima-residual-en-pacientes-con-mieloma-multiple-sometidos-a-quimioterapia\/","title":{"rendered":"Valor del inmunofenotipo y del an\u00e1lisis del contenido de adn por citometr\u00eda de flujo en la investigaci\u00f3n de enfermedad m\u00ednima residual en pacientes con mieloma m\u00faltiple sometidos a quimioterapia intensiva"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mateo Manzanera M. Gema <\/strong><\/h2>\n<p>El an\u00e1lisis multiparam\u00e9trico por inmunofenotipo constituye una herramienta \u00fatil para la investigaci\u00f3n del comportamiento de c\u00e9lulas plasm\u00e1ticas (cp) en mieoloma m\u00faltiple (mm) ya que permite establecer una clara distinci\u00f3n entre cp mielomatosa y su contrapartida normal. Esta discriminaci\u00f3n se basa en la presencia de fenotipos aberrantes (&gt;90% de mm) que nunca se encuentran en las cp normales. El l\u00edmite de sensibilidad del inmunofenotipo es &gt;10-4 (detecci\u00f3n de una cp aberrante entre, al menos 10.000 c\u00e9lulas normales). Ambas caracter\u00edsticas -especificidad y sensibilidad-, hace del inmunofenotipo una t\u00e9cnica ide\u00f3nea para valorar cambios en el clon de cp inducidos tras tratamiento.  el presente estudio se basa en el an\u00e1lisis inmunofenot\u00edpico del comportamiento de cp con un doble objetivo:  1,- comparar dos opciones terap\u00e9uticas-quimioterapia a altas dosis seguida de taspe versus quimioterapia convencional.  2,- establecer el impacto de este an\u00e1lisis sobre el pron\u00f3stico de la enfermedad.  se han seleccionado un total de 87 pacientes al protocolo pethema-94. tras la administraci\u00f3n de cuatro ciclos de vbcmp\/vbad, se aleatorizaron en dos ramas: 47 casos se sometieron a taspe y en 40 casos se administraron ocho ciclos adicionales de la misma quimioterapia.  ambos grupos de pacientes presentaban caracter\u00edsticas cl\u00ednico-biol\u00f3gicas similares. Para la identificaci\u00f3n de las cp, se dise\u00f1\u00f3 un panel de anticuerpos monoclonales en cu\u00e1druples combinaciones (cd38\/56 19\/45: cd138\/28\/33\/38; cd20\/117\/138\/38) y la informaci\u00f3n inmunofenot\u00edpica se adquiri\u00f3 en un cit\u00f3metro de flujo facscalibur (becton\/dickinson, san jos\u00e9, ca) en dos pasos consecutivos utilizando \u00ablive-gate\u00bb espec\u00edficos para cp.  el estudio se realiz\u00f3 a los 3 meses del taspe y al mes de finalizar los 12 ciclos de quimioterapia y se analizaron tres par\u00e1metros: el porcentaje absoluto de:  1,- cp mielomatosas (%cp-mm).  2,- cp normales (%cp-n) referido<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor del inmunofenotipo y del an\u00e1lisis del contenido de adn por citometr\u00eda de flujo en la investigaci\u00f3n de enfermedad m\u00ednima residual en pacientes con mieloma m\u00faltiple sometidos a quimioterapia intensiva<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor del inmunofenotipo y del an\u00e1lisis del contenido de adn por citometr\u00eda de flujo en la investigaci\u00f3n de enfermedad m\u00ednima residual en pacientes con mieloma m\u00faltiple sometidos a quimioterapia intensiva <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mateo Manzanera M. Gema <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/11\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Fernando San Miguel Izquierdo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio L\u00f3pez borrasca <\/li>\n<li>felipe Luis Prosper cardoso (vocal)<\/li>\n<li>Francisco Javier Batlle fontrodona (vocal)<\/li>\n<li>Mar\u00eda  consuelo Juan a Del ca\u00f1izo fernandez roldan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mateo Manzanera M. Gema El an\u00e1lisis multiparam\u00e9trico por inmunofenotipo constituye una herramienta \u00fatil para la investigaci\u00f3n del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,218,195,139,156,9386],"tags":[9427,18255,9708,9596,9401,44412],"class_list":["post-13710","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-hematologia","category-hemopatologia","category-medicina-interna","category-patologia","category-salamanca","tag-antonio-lopez-borrasca","tag-felipe-luis-prosper-cardoso","tag-francisco-javier-batlle-fontrodona","tag-jesus-fernando-san-miguel-izquierdo","tag-maria-consuelo-juan-a-del-canizo-fernandez-roldan","tag-mateo-manzanera-m-gema"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13710"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13710\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}